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目的探讨阿司匹林对体外受精-胚胎移植/卵胞浆内单精子注射(IVF/ICSI)周期结局的影响。方法在本生殖中心IVF/ICSI周期中行常规长方案降调治疗患者共1,264个周期,采用前瞻性随机法,分为服用阿司匹林(实验组)684周期,未服用阿司匹林(对照组)580周期。实验组于前一周期黄体高峰期用促性腺激素释放激动剂(GnRHa)时加服阿司匹林(75 mg/d),于移植后14 d查血人绒毛膜促性腺激素(hCG)升高即停药。比较两组子宫内膜厚度、超促排卵及妊娠结果。结果实验组子宫内膜厚度(11.26±2.39)mm高于对照组(9.94±2.28)mm(P<0.05),但无明显临床意义。前者临床妊娠率(41%)高于后者(37%),但无显著性差异。余各项指标两组间均无明显差异(P>0.05)。结论在超促排卵过程中,加服阿司匹林,对获卵数,胚胎质量等无显著影响。虽可增加子宫内膜厚度,但临床意义不大。
Abstract：Objective:To determine the effect of low-dose aspirin on endometrial reception,ovarian response,and pregnancy rates in patients undergoing in-vitro fertilization(IVF) cycles or intracytoplasmic sperm injection(ICSI) cycles.Methods:A total of 1,264 long protocol cycles,from May 2006 to April 2007,were randomized to receive 75 mg of aspirin(n=684) or received no treatment(n=580) daily.Treatment was started on the first day of controlled ovarian stimulation.It was continued until menstruation or a negative pregnancy test.The main outcome measures were the thickness of endometrium,the number of oocytes,number and quality of embryos,the clinical pregnancy rate(PR).Results:The endometrial thickness in the aspirin group was significantly thicker than that of nontreated group(P<0.05),but there was no significant difference in clinic.Clinical PR was higher in the aspirin group(41%) than that of non-treatment group(37%),but there was no statistically significant difference.The outcome of ovarian responses,such as the mean number of oocytes,the total mean number of embryos,did not differ in groups. Conclusions:Low-dose aspirin has no effect on the number of oocytes,the quality of embryos.Maybe low-dose aspirin can improve the thickness of endometrium,and have any beneficial effect on clinical PR,which has no significance in clinic.
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基本信息:
中图分类号:R714.8
引用信息:
[1]梁琳琳,朱桂金.低剂量阿司匹林在体外受精-胚胎移植/卵胞浆内单精子注射周期中的作用[J].生殖医学杂志,2008,17(06):460-464.
2008-12-15
2008-12-15