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细胞因子是细胞与细胞间相互沟通的信号分子,细胞因子之间彼此诱生,相互协同或拮抗作用介导并维持细胞间的协调关系。男性精浆中白细胞介素(IL)-2、IL-6、肿瘤坏死因子(TNF)-α等细胞因子对男性生殖有一定的影响。
Abstract:Cytokines are group of kinetic proteins and peptides that are used in organisms as signaling compounds.Cytokines,which could be induced by each other,mediate and maintain the intercellular communication.The effect of them is also mutually synergistic or antagonistic.It is believed that the interleukin(IL)-2,interleukin(IL)-6,and tumor necrosis factor(TNF)-α in seminal plasma play a versatile role in male reproduction.
[1]Hedger MP,Meinhardt A.Cytokines and the immune-testic-ular axis[J].J Reprod Immunol,2003,58(1):1-26.
[2]熊承良,吴明章,刘继红,等.人类精子学[M].武汉:湖北科学技术出版社,2002:182-190.
[3]孙卫民,王惠琴.细胞因子研究方法学[M].北京:人民卫生出版社,1999:367-619.
[4]Laflamme J,Akoum A,Leclerc P.Induction of human spermcapacitation and protein tyrosine phosphorylation by endometrialcells and interleukin-6[J].Mol Hum Reprod,2005,11(2):141-150.
[5]Basu S,Aballa TC,Ferrell SM,et al.Inflammatory cyto-kine concentrations are elevated in seminal plasma of menwith spinal cord injuries[J].J Androl,2004,25(2):250-254.
[6]Friebe K,Bohring C,Skrzypek J,et al.Levels of interleu-kin-6 and interleukin-8 in seminal fluid of men attending anandrological clinic[J].Andrologia,2003,35(2):126-129.
[7]Yoshida S,Harada T,Iwabe T,et al.A combination ofinterleukin-6 and its soluble receptor impairs sperm motility:implications in infertility associated with endometriosis[J].Hum Reprod,2004,19(8):1821-1825.
[8]资捷,宋平.IL-6对人精子顶体反应影响机制的初步探讨[J].中华男科学杂志,2006,12(6):528-530.
[9]Laflamme J,Akoum A,Leclerc P.Induction of human spermcapacitation and protein tyrosine phosphorylation by endome-trial cells and interleukin-6[J].Mol Hum Reprod,2005,11(2):141-150.
[10]Nandipati KC,Pasqualotto FF,Thomas AJ Jr,et al.Relationship of interleukin-6 with semen characteristics andoxidative stress in vasectomy reversal patients[J].Androlo-gia,2005,37(4):131-134.
[11]Sanocka D,Jedrzejczak P,Szumala-Kaekol A,et al.Malegenital tract inflammation:The role of selected interleukinsin regulation of pro-oxidant and antioxidant enzymatic sub-stances in seminal plasma[J].J Androl,2003,24(3):448-455.
[12]Diemer T,Hales DB,Weidner W.Immune-endocrine inter-actions and Leydig cell function:the role of cytokines[J].Andrologia,2003,35(1):55-63.
[13]Furuya Y,Akashi T,Fuse H.Soluble Fas and interleukin-6and interleukin-8 levels in seminal plasma of infertile men[J].Arch Androl,2003,49(6):449-452.
[14]Potashnik H,Elhija MA,Lunenfeld E,et al.Interleukin-6expression during normal maturation of the mouse testis[J].Eur Cytokine Netw,2005,16(2):161-165.
[15]柳靖,王益鑫,吴裕伦,等.精浆中细胞因子检测及其意义[J].中华男科学,2002,16(4),295-298.
[16]Li MW,Xia W,Mruk DD,et al.Tumor necrosis factor a re-versibly disrupts the blood-testis barrier and impairs Sertoli-germ cell adhesion in the seminiferous epithelium of adult rattestes[J].J Endocrinol,2006,190(2):313-329.
[17]Wong CH,Cheng CY.The blood-testis barrier:its biology,regulation,and physiological role in spermatogenesis[J].Curr Top Dev Biol,2005,71(13):263-296.
[18]Delfino FJ,Boustead JN,Fix C,et al.NF-kappa B andTNF-αstimulate androgen receptor expression in Sertoli cells[J].Mol Cell Endocrinol,2003,201(1-2):1-12.
[19]Khazanov E,Simberg D,Barenholz Y.Lipoplexes,preparedfrom cationic liposomes and mammalian DNA induce CpG-independent,direct cytotoxic effects in cell cultures and inmice[J].J Gene Med,2006,8(8):998-1007.
[20]Martinets P,Proverbio F,Camejo MI.Sperm lipid peroxda-tion and pro-inflammatory cytokines[J].Asian J Androl,2007,9(1):102-107.
[21]边淑玲,金宏波,王淑珍,等.干扰素-γ和肿瘤坏死因子-α对精子受精能力的影响及机制初探[J].中华男科学杂志,2007,13(8):681-684.
[22]Benbrahim-Tallaa L,Boussouar F,Rey C,et al.Tumor nec-rosis factor-αinhibits glutathione S-transferase-αexpressionin cultured porcine Sertoli cells[J].J Endocrinol,2002,175(3):803-812.
[23]Perdichizzi A,Nicoletti F,La Vignera S,et al.Effects oftumour necrosis factor-αon human sperm motility and apop-tosis[J].J Clin Immunol,2007,27(2):152-162.
[24]边疆,郭贤坤,熊承良,等.体外rhTNF-α对人精子运动、线粒体功能影响的实验研究[J].中华男科学,2004,10(6):415-419.
[25]Gruschwitz MS,Brezinschek R,Brezinschek HP.Cytokinelevels in the seminal plasma of infertile males[J].J Androl,1996,17(2):158-163.
基本信息:
中图分类号:R321.1
引用信息:
[1]王仕琪,熊承良.细胞因子对精子发生及其功能的影响[J].生殖医学杂志,2008(05):393-396.
基金信息:
国家自然科学基金项目(30570679)
2008-10-15
2008-10-15