生殖医学杂志

目的 探索不孕症女性移植囊胚数目意愿的现状及其影响因素。方法 2023年1—12月于广州医科大学附属第三医院生殖医学中心对906名不孕症女性进行问卷调查，采用自制的一般资料调查问卷收集其人口学资料，采用自制的调查问卷收集其移植囊胚数目意愿现状及其影响因素。结果 906名不孕症女性中，29.7%的女性选择单囊胚移植，70.3%的女性选择双囊胚移植。选择单囊胚移植的女性中，38.3%的女性认为“单囊胚移植可以减少母体发生流产等妊娠相关疾病的风险”。选择双囊胚移植的女性中，97.2%的女性认为“双囊胚移植的怀孕成功率较高”,若告知其怀双胎所存在的风险后，其中63.4%的女性表示继续选择双囊胚移植，36.6%的女性表示不会选择双囊胚移植。二元Logistic回归分析结果显示，不孕症女性移植囊胚数目意愿的影响因素为工作情况[OR=1.224,95%CI(1.034,1.450)]、年龄[OR=0.809,95%CI(0.688,0.952)]、学历[OR=0.794,95%CI(0.655,0.963)]和生育史[OR=0.708,95%CI(0.565,0.888)]。结论 临床上的不孕症女性以双囊胚移植意愿居多，对囊胚移植数目的认知存在一定的误区，对双胎妊娠风险了解不足。影响因素是多方面的，受其工作情况、年龄、学历和生育史的影响。这提醒医护人员应结合患者的年龄、学历、工作情况、生育史等情况，制定个性化的科普教育内容，充分告知相关风险，有助于更好地为不孕症女性提供移植囊胚数目的建议，帮助她们制定更合理的助孕计划，保证该群体孕期的健康安全。

Objective:To explore the current status and influencing factors of the number of embryos desired for transfer among infertile women.Methods:A questionnaire survey was conducted on 906 infertile women from January to December 2023 at Center for Reproductive Medicine, The Third Affiliated Hospital of Guangzhou Medical University. Demographic data were collected using a self-designed questionnaire, and the current status and influencing factors of the number of embryos desired for transfer were collected using another self-designed questionnaire.Results:Among the 906 infertile women, 29.7% chose single embryo transfer, while 70.3% chose double embryo transfer. Among those who chose single embryo transfer, 38.3% believed that it could reduce the risk of pregnancy-related diseases such as miscarriage. Among those who chose double embryo transfer, 97.2% believed that it had a higher success rate, and after being informed of the risks of conceiving twins, 63.4% still preferred double embryo transfer, while 36.6% did not. Binary logistic regression analysis revealed that the influencing factors of the number of embryos desired for transfer among infertile women were work status [OR=1.224,95%CI(1.034,1.450)],age [OR=0.809,95%CI(0.688,0.952)],the education level [OR=0.794,95%CI(0.655,0.963)],and reproductive history [OR=0.708,95%CI(0.565,0.888)].Conclusions:In clinical practice, infertile women show a preference for double embryo transfer, with some misconceptions regarding the number of embryos to transfer and inadequate understanding of the risks of conceiving twins. Many influencing factors, such as work status, age, the education level and reproductive history were found. This highlights the importance of personalized education tailored to factors such as age, the education level, work status, and reproductive history, and informing patients of related risks so as to provide recommendations for embryo transfer number and assist them in the development of a more reasonable fertility plan to ensure the healthy and safety of such pregnant women.