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亚甲基四氢叶酸还原酶(MTHFR)是人体内催化叶酸代谢的关键酶,且具有基因多态性。越来越多的研究表明MTHFR的基因多态性与不孕不育、先天性心脏病、神经管缺陷、妊娠期高血压等疾病及孕期叶酸的补充剂量密切相关,严重影响生育质量。本文将就MTHFR的基因多态性在生殖领域的研究状况作一综述。
Abstract：Methylenefourfolate reductase(MTHFR)is a key enzyme in folate metabolism,which has a variety of gene polymorphisms.A growing number of studies have shown that gene polymorphism of MTHFR is closely related to infertility,congenital heart disease,neural tube defects,pregnancy hypertension and individualized use of folic acid during pregnancy,which seriously affects the quality of fertility.The research status of MTHFRgene polymorphism in the field of reproduction is reviewed in this paper.
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基本信息:
中图分类号:R714
引用信息:
[1]李静,陈力,邓彩凤,等.亚甲基四氢叶酸还原酶基因多态性在生殖方面的研究进展[J].生殖医学杂志,2019,28(10):1242-1247.
2019-10-12
2019-10-12