| 408 | 3 | 116 |
| 下载次数 | 被引频次 | 阅读次数 |
内分泌干扰物广泛暴露于人类生存环境中,从胚胎期便可影响到女性,对女性生殖产生终生影响。双酚A是目前研究的最广泛的内分泌干扰物之一。现有证据表明在不同的动物和人类模型中,双酚A可以减少原始卵泡池储备并扰乱卵巢功能,如类固醇生成和月经周期等,从而降低生育能力。同时双酚A暴露所致的女性卵巢功能下降,可能会进一步影响这些不孕女性辅助生殖的妊娠结局。因此,探讨双酚A对卵巢功能影响的机制,将有助于预防双酚A对卵巢功能的损害甚至改善育龄期女性的卵巢功能,提高其生育力。本文从双酚A对卵泡形成、卵母细胞发育、类固醇生成和妊娠结局的影响等方面进行综述。
Abstract:Endocrine disruptors are widely exist in human living environment, which can affect women from embryonic stage and can have lifelong effects on female reproduction. Bisphenol A is one of the most widely studied endocrine disruptors. The available evidence shows that bisphenol A can reduce the reserve of primordial follicle pool and disturb ovarian function, such as steroidogenesis and menstrual cycle, so as reduce fertility in different animal and human models. Bisphenol A exposure can result in reduced ovarian function in women, which may further affect pregnancy outcome of assisted reproduction in the infertile women. Therefore, exploring the mechanism of bisphenol A on ovarian function is helpful to prevent the damage of bisphenol A on ovarian function, and even improve the ovarian function and fertility of women of childbearing age. The paper reviews the effects of bisphenol A on follicular formation, oocyte development, steroidogenesis and pregnancy outcome.
[1] Huang J,Zeng H.The Influence of environmental factors on ovarian function,follicular genesis,and oocyte quality[J].Adv Exp Med Biol,2021,1300:41-62.
[2] Balaguer P,Delfosse V,Grimaldi M,et al.Structural and functional evidences for the interactions between nuclear hormone receptors and endocrine disruptors at low doses[J].C R Biol,2017,340:414-420.
[3] Lauretta R,Sansone A,Sansone M,et al.Endocrine disrupting chemicals:effects on endocrine glands[J].Front Endocrinol(Lausanne),2019,10:178.
[4] Sifakis S,Androutsopoulos VP,Tsatsakis AM,et al.Human exposure to endocrine disrupting chemicals:effects on the male and female reproductive systems[J].Environ Toxicol Pharmacol,2017,51:56-70.
[5] Zulkifli S,Rahman AA,Kadir SHSA,et al.Bisphenol A and its effects on the systemic organs of children[J].Eur J Pediatr,2021,180:3111-3127.
[6] Calafat AM,Ye X,Wong LY,et al.Exposure of the U.S.population to bisphenol A and 4-tertiary octylphenol:2003-2004[J].Environ Health Perspect,2008,116:39-44.
[7] Pivonello C,Muscogiuri G,Nardone A,et al.Bisphenol A:an emerging threat to female fertility[J].Reprod Biol Endocrinol,2020,18:22.
[8] 方健叶,杨菁,郭悦,等.双酚A与多囊卵巢综合征相关性的研究进展[J].生殖医学杂志,2014,23:73-77.
[9] Zhang T,Li L,Qin XS,et al.Di-(2-ethylhexyl)phthalate and bisphenol A exposure impairs mouse primordial follicle assembly in vitro[J].Environ Mol Mutagen,2014,55:343-353.
[10] Peretz J,Vrooman L,Ricke WA,et al.Bisphenol a and reproductive health:update of experimental and human evidence,2007-2013[J].Environ Health Perspect,2014,122:775-786.
[11] Santamaria C,Durando M,Toro MM,et al.Ovarian dysfunctions in adult female rat offspring born to mothers perinatally exposed to low doses of bisphenol A[J].J Steroid Biochem Mol Biol,2016,158:220-230.
[12] Chao HH,Zhang XF,Chen B,et al.Bisphenol A exposure modifies methylation of imprinted genes in mouse oocytes via the estrogen receptor signaling pathway[J].Histochem Cell Biol,2012,137:249-259.
[13] Ijaz S,Ullah A,Shaheen G,et al.Exposure of BPA and its alternatives like BPB,BPF,and BPS impair subsequent reproductive potentials in adult female Sprague Dawley rats[J].Toxicol Mech Methods,2020,30:60-72.
[14] Souter I,Smith KW,Dimitriadis I,et al.The association of bisphenol-A urinary concentrations with antral follicle counts and other measures of ovarian reserve in women undergoing infertility treatments[J].Reprod Toxicol,2013,42:224-231.
[15] Lin M,Hua R,Ma J,et al.Bisphenol A promotes autophagy in ovarian granulosa cells by inducing AMPK/mTOR/ULK1 signalling pathway[J].Environ Int,2021,147:106298.
[16] Tang C,Zhang J,Liu P,et al.Chronic exposure to low dose of bisphenol A causes follicular atresia by inhibiting kisspeptin neurons in anteroventral periventricular nucleus in female mice[J].Neurotoxicology,2020,79:164-176.
[17] Zhang HQ,Zhang XF,Zhang LJ,et al.Fetal exposure to bisphenol A affects the primordial follicle formation by inhibiting the meiotic progression of oocytes[J].Mol Biol Rep,2012,39:5651-5657.
[18] Liu B,Zhou S,Yang C,et al.Bisphenol A deteriorates egg quality through HDAC7 suppression[J].Oncotarget,2017,8:92359-92365.
[19] Zhang Y,Gao J,Xu P,et al.Low-dose bisphenol A disrupts gonad development and steroidogenic genes expression in adult female rare minnow Gobiocypris rarus[J].Chemosphere,2014,112:435-442.
[20] Liu Y,Wang L,Zhu L,et al.Bisphenol A disturbs transcription of steroidogenic genes in ovary of rare minnow Gobiocypris rarus via the abnormal DNA and histone methylation[J].Chemosphere,2020,240:124935.
[21] Risalde MA,Molina AM,Lora AJ,et al.Immunohistochemical expression of aromatase cyp19a1a and cyp19a1b in the ovary and brain of zebrafish(Danio rerio)exposed to different concentrations of bisphenol A[J].Aquat Toxicol,2021,237:105876.
[22] Song W,Lu H,Wu K,et al.Genetic evidence for estrogenicity of bisphenol A in zebrafish gonadal differentiation and its signalling mechanism[J].J Hazard Mater,2020,386:121886.
[23] Shi J,Liu C,Chen M,et al.The interference effects of bisphenol A on the synthesis of steroid hormones in human ovarian granulosa cells[J].Environ Toxicol,2021,36:665-674.
[24] Eldefrawy F,Xu HS,Pusch E,et al.Modulation of folliculogenesis in adult laying chickens by bisphenol A and bisphenol S:Perspectives on ovarian morphology and gene expression[J].Reprod Toxicol,2021,103:181-190.
[25] Santangeli S,Consales C,Pacchierotti F,et al.Transgenerational effects of BPA on female reproduction[J].Sci Total Environ,2019,685:1294-1305.
[26] Wei Y,Han C,Li S,et al.Maternal exposure to bisphenol A during pregnancy interferes ovaries development of F1 female mice[J].Theriogenology,2020,142:138-148.
[27] Shi M,Sekulovski N,MacLean JA,et al.Prenatal exposure to bisphenol A analogues on female reproductive functions in mice[J].Toxicol Sci,2019,168:561-571.
[28] Mahalingam S,Ther L,Gao L,et al.The effects of in utero bisphenol A exposure on ovarian follicle numbers and steroidogenesis in the F1 and F2 generations of mice[J].Reprod Toxicol,2017,74:150-157.
[29] Biswas S,Ghosh S,Samanta A,et al.Bisphenol A impairs reproductive fitness in zebrafish ovary:Potential involvement of oxidative/nitrosative stress,inflammatory and apoptotic mediators[J].Environ Pollut,2020,267:115692.
[30] Gao Z,Gao X,Fan W,et al.Bisphenol A and genistein have opposite effects on adult chicken ovary by acting on ERalpha/Nrf2-Keap1-signaling pathway[J].Chem Biol Interact,2021,347:109616.
[31] Fan X,Hou T,Jia J,et al.Discrepant dose responses of bisphenol A on oxidative stress and DNA methylation in grass carp ovary cells[J].Chemosphere,2020,248:126110.
[32] Banerjee O,Singh S,Prasad SK,et al.Inhibition of catalase activity with 3-amino-1,2,4-triazole intensifies bisphenol A(BPA)-induced toxicity in granulosa cells of female albino rats[J].Toxicol Ind Health,2018,34:787-797.
[33] Bilgi A,Abali R,Bilgi PT,et al.The apoptotic effects of bisphenol A exposure on the rat ovary:an experimental study[J].Environ Sci Pollut Res Int,2019,26:10198-10203.
[34] Ishtiaq A,Ali T,Bakhtiar A,et al.Melatonin abated Bisphenol A-induced neurotoxicity via p53/PUMA/Drp-1 signaling[J].Environ Sci Pollut Res Int,2021,28:17789-17801.
[35] Bloom MS,Saal FSV,Kim D,et al.Serum unconjugated bisphenol A concentrations in men may influence embryo quality indicators during in vitro fertilization[J].Environ Toxicol Pharmacol,2011,32:319-323.
[36] Ehrlich S,Williams PL,Missmer SA,et al.Urinary bisphenol A concentrations and implantation failure among women undergoing in vitro fertilization[J].Environ Health Perspect,2012,120:978-983.
[37] Ehrlich S,Williams PL,Missmer SA,et al.Urinary bisphenol A concentrations and early reproductive health outcomes among women undergoing IVF[J].Hum Reprod,2012,27:3583-3592.
[38] Mínguez-Alarcón L,Messerlian C,Bellavia A,et al.Urinary concentrations of bisphenol A,parabens and phthalate metabolite mixtures in relation to reproductive success among women undergoing in vitro fertilization[J].Environ Int,2019,126:355-362.
[39] 沈娟.BPA与TCS对女性生殖的影响及相关分子机制研究[D].杭州:浙江大学,2020.
基本信息:
中图分类号:R114
引用信息:
[1]谷旭照,沈豪飞,高敏,等.双酚A对卵巢功能的影响研究进展[J].生殖医学杂志,2022,31(10):1445-1449.
基金信息:
兰大一院院内基金(ldyyyn2021-89)
2021-12-18
2021
2022-04-05
2022-08-30
2022
1
2022-10-15
2022-10-15