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目的探讨不育患者输卵管功能状态与宫腔内人工授精(IUI)妊娠率的关系,为输卵管功能不良患者选择辅助生育方式提供依据。方法回顾性分析单纯男方因素不育患者355例、636个IUI周期,按输卵管通畅程度患者分为三组:A组双侧通畅,B组单侧通畅,C组双侧通而不畅。比较各组3个周期IUI的妊娠率和累积妊娠率。结果C组妊娠率及累计妊娠率显著低于A组(P<0.05);B组妊娠率显著低于A组(P<0.05),累积妊娠率低于A组,统计学无显著差异;C组妊娠率低于B组,统计学无显著差异,累积妊娠率显著低于B组(P<0.05)。结论单侧输卵管通畅患者可以选择3个周期IUI作为初步治疗;双侧输卵管通而不畅、双侧输卵管粘连分离或造口术后患者若尝试1个周期IUI后仍不育需及时采用其他治疗措施。
Abstract：Objective:To investigate the relationship between tubal pathology and the pregnancy rate of intra-uterine insemination(IUI),in order to provide the reference data to the treatment options for the patients with tubal problem.Methods:The retrospective study consisted of 355 patients with male subfertility treated at our department for 636 IUI cycles.The patients were divided into three groups according to the tubal potency:(A)bilateral tubal potent group,(B)unilateral tubal potent group,and(C)bilateral tubal problem group.The pregnancy rate and cumulative pregnancy rate of each group were compared.Results:Both pregnancy rate and cumulative pregnancy rate in group C were significantly lower than those in group A.The pregnancy rate of group B was significantly lower than that of group A,while the cumulative pregnancy rate was also lower,but without statistical significance.The cumulative pregnancy rate in group C was statistically lower than that in group B,but the difference of pregnancy rate was not significant.Conclusions:Patients with unilateral tubal potency could choose IUI for 3 cycles as an initial treatment,but the patients with two-sided tubal problem would turn to other treatments after one abortive IUI cycle.
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基本信息:
中图分类号:R714.8
引用信息:
[1]付敏,李蓉,杨伟洪,等.宫腔内人工授精妊娠率与输卵管功能状态的研究[J].生殖医学杂志,2008,17(06):453-456.
2008-12-15
2008-12-15