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目的探讨新鲜周期人绒毛膜促性腺激素(HCG)日血清雌二醇(E2)水平是否可作为预测活产的指标。方法回顾性分析2013年1月至2016年12月在中国医科大学附属盛京医院生殖中心首次行新鲜周期移植患者的4 200个周期,根据HCG日血清E2水平将患者分为3组,A组:E2≤9 175pmol/L;B组:9 175pmol/L
Objective:To determine if the serum E2 concentration on HCG day can be used as a predictor of live birth rate.Methods:A retrospective investigation was made based on 4 200 cycles with the first fresh embryo transfer conducted in our center from January 2013 to December 2016.The patients were divided into three groups according to the E2 level on HCG day:group A with E2≤9 175 pmol/L,group B with 9 175 pmol/L
[1]Ozdegirmenci O,Dilbaz S,Cinar O,et al.Can serum oestradiol be a predictor of quality of oocytes and embryos,maturation of oocytes and pregnancy rate in ICSI cycles?[J].Gynecol Endocrinol,2011,27:279-285.
[2]Chenette PE,Sauer MV,Paulson RJ.Very high serum estradiol levels are not detrimental to clinical outcome of in vitro fertilization[J].Fertil Steril,1990,54:858-863.
[3]Blazar AS,Hogan JW,Frankfurter D,et al.Serum estradiol positively predicts outcomes in patients undergoing in vitro fertilization[J].Fertil Steril,2004,81:1707-1709.
[4]Kummer N,Benadiva C,Feinn R,et al.Factors that predict the probability of a successful clinical outcome after induction of oocyte maturation with a gonadotropin-releasing hormone agonist[J].Fertil Steril,2011,96:63-68.
[5]Chen QJ,Sun XX,Li L,et al.Effects of ovarian high response on implantation and pregnancy outcome during controlled ovarian hyperstimulation(with GnRH agonist and rFSH)[J].Acta Obstet Gynecol Scand,2007,86:849-854.
[6]Arslan M,Bocca S,Ozturk EO,et al.Cumulative exposure to high estradiol levels during the follicular phase of IVF cycles negatively affects implantation[J].J Assist Reprod Genet,2007,24:111-117.
[7]Wu CH,Kuo TC,Wu HH,et al.High serum estradiol levels are not detrimental to in vitro fertilization outcome[J].Taiwan J Obstet Gynecol,2007,46:54-59.
[8]Kong GWS,Cheung LP,Haines CJ,et al.Comprehensive assessment of serum estradiol impact on selected physiologic markers observed during invitro fertilization and embryo transfer cycles[J].J Exp Clin Assist Reprod,2009,6:5-13.
[9]Yoldemir T,Fraser IS.The effect of elevated serum estradiol levels on the day of human chorionic gonadotropin injection on pregnancy outcomes in an assisted reproduction program[J].Aust N Z J Obstet Gynecol,2009,49:545-550.
[10]Kyrou D,Popovic-Todorovic B,Fatemi HM,et al.Does the estradiol level on the day of human chorionic gonadotrophin administration have an impact on pregnancy rates in patients treated with rec-FSH/GnRH antagonist?[J].Hum Reprod,2009,24:2902-2909.
[11]Zavy MT,Craig LTB,Wild RA,et al.In high responding patients undergoing an initial IVF cycle,elevated estradiol on the day of hCG has no effect on live birth rate[J].Reprod Biol Endocrinol,2014,12:119.
[12]Demko ZP,Simon AL,McCoy RC,et al.Effects of maternal age on euploidy rates in a large cohort of embryos analyzed with 24-chromosome single-nucleotide polymorphism-based preimplantation genetic screening[J].Fertil Steril,2016,105:1307-1313.
[13]Steiner AZ,Jukic AMZ.Impact of female age and nulligravidity on fecundity in an older reproductive age cohort.[J].Fertil Steril,2016,105:1584-1588.
[14]Kondapalli LA,Molinaro TA,Sammel MD,et al.A decrease in serum estradiol levels after human chorionic gonadotropin administration predicts significantly lower clinical pregnancy and live birth rates in in vitro fertilization cycles[J].Hum Reprod,2012,27:2690-2697.
[15]Imudia AN,Awonuga AO,Doyle JO,et al.Peak serum estradiol level during controlled ovarian hyperstimulation is associated with increased risk of small for gestational age and preeclampsia in singleton pregnancies after in vitro fertilization[J].Fertil Steril,2012,97:1374-1379.
[16]Wu Z,Li R,Ma Y,et al.Effect of HCG-day serum progesterone and oestradiol concentrations on pregnancy outcomes in GnRH agonist cycles[J/OL].Reprod Biomed Online,2012,24:511-520.
[17]Imudia AN,Goldman RH,Awonuga AO,et al.The impact of supraphysiologic serum estradiol levels on peri-implantation embryo development and early pregnancy outcome following in vitro fertilization cycles[J].J Assist Reprod Genet,2014,31:65-71.
[18]Pereira N,Reichman DE,Goldschlag DE,et al.Impact of elevated peak serum estradiol levels during controlled ovarian hyperstimulation on the birth weight of term singletons from fresh IVF-ET cycles[J].J Assist Reprod Genet,2015,32:527-532.
[19]Wang M,Hao C,Bao H,et al.Effect of elevated estradiol levels on the hCG administration day on IVF pregnancy and birth outcomes in the long GnRH-agonist protocol:analysis of3393cycles[J].Arch Gynecol Obstet,2016,295:1-8.
[20]王晓博,谢青贞,吴开林,等.HCG扳机前雌激素下降对IVF/ICSI助孕妊娠结局的影响[J].生殖医学杂志,2016,25:782-786.
[21]Basir GS,Wai-Sum O,Ng EHY,et al.Morphometric analysis of peri-implantation endometrium in patients having excessively high oestradiol concentrations after ovarian stimulation[J].Hum Reprod,2001,16:435-440.
[22]Arce JC,Smitz J.Live-birth rates after HP-hMG stimulation in the long GnRH agonist protocol:association with midfollicular hCG and progesterone concentrations,but not with LH concentrations[J].Gynecol Endocrinol,2013,29:46-50.
基本信息:
中图分类号:R714.8
引用信息:
[1]董萌,邱佳慧,谭季春.HCG日血清雌激素水平对不同年龄段女性活产率的预测价值[J].生殖医学杂志,2019,28(03):249-257.
2019-03-15
2019-03-15