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Objective:To investigate the relationship between the changes of serotonin metabolism and the hot flushes in climacteric women.Methods:Ninety eight climacteric women,aged 40-60,were enrolled and divided into 4 groups:Group A:20 cases of early menopausal transition.Group B:26 cases of late menopausal transition,with skip of periods 3-12 months.Group C:28 cases of early postmenopause(1-3 yrs).Group D:24 cases of late postmenopause(>3-6 yrs).Twelve normal women of reproductive age(24±3yrs)were served as young controls.Fifty two postmenopausal women were subdivided into 3 groups according to the presence or the absence of hot flushes:(1)postmenopausal controls without hot flush:17 cases,(2)mild hot flushes group:20 cases,fewer ≤5 times/d,(3)severe hot flushes group:15 cases,more than 5 times/d.Plasma concentrations of tryptophan(TP),5-hydroxytryptophane(5-HTP),5-hydroxytryptamine(5-HT or serotonin),5-hydroxyindoleacetic acid(5-HIAA)and luteinizing hormone(LH)were measured in all participants by high pressure liquid chromatography-fluorescence spectrophotometer(HPLC-FS).The relationship between serotonin metabolic parameters and menopause,hot flushes were analysed.Results:(1)Mean 5-HT and 5-HIAA concentrations in plasma were significantly higher in climacteric women than those in young controls,especially in Group B.Mean 5-HTP and 5-HT levels were higher and 5-HIAA lower in Group D as compared with those of young controls.(2)Plasma 5-HT levels was positively correlated to luteinizing hormone concentration in postmenopausal women(P<0.01).(3)In the mild hot flushes group,only plasma 5-HTP levels were significantly higher than that in the non-hot flushes group.In severe hot flushes group,plasma 5-HT and 5-HTP contents were significantly higher and 5-HIAA/5-HT ratio lower than those in the non-hot flushes groups.Conclusion:The results suggest that the catabolic disorder of serotonin maybe involve in the underling mechanism of hot flushes in postmenopausal women.
Abstract：Objective:To investigate the relationship between the changes of serotonin metabolism and the hot flushes in climacteric women.Methods:Ninety eight climacteric women,aged 40-60,were enrolled and divided into 4 groups:Group A:20 cases of early menopausal transition.Group B:26 cases of late menopausal transition,with skip of periods 3-12 months.Group C:28 cases of early postmenopause(1-3 yrs).Group D:24 cases of late postmenopause(>3-6 yrs).Twelve normal women of reproductive age(24±3yrs)were served as young controls.Fifty two postmenopausal women were subdivided into 3 groups according to the presence or the absence of hot flushes:(1)postmenopausal controls without hot flush:17 cases,(2)mild hot flushes group:20 cases,fewer ≤5 times/d,(3)severe hot flushes group:15 cases,more than 5 times/d.Plasma concentrations of tryptophan(TP),5-hydroxytryptophane(5-HTP),5-hydroxytryptamine(5-HT or serotonin),5-hydroxyindoleacetic acid(5-HIAA)and luteinizing hormone(LH)were measured in all participants by high pressure liquid chromatography-fluorescence spectrophotometer(HPLC-FS).The relationship between serotonin metabolic parameters and menopause,hot flushes were analysed.Results:(1)Mean 5-HT and 5-HIAA concentrations in plasma were significantly higher in climacteric women than those in young controls,especially in Group B.Mean 5-HTP and 5-HT levels were higher and 5-HIAA lower in Group D as compared with those of young controls.(2)Plasma 5-HT levels was positively correlated to luteinizing hormone concentration in postmenopausal women(P<0.01).(3)In the mild hot flushes group,only plasma 5-HTP levels were significantly higher than that in the non-hot flushes group.In severe hot flushes group,plasma 5-HT and 5-HTP contents were significantly higher and 5-HIAA/5-HT ratio lower than those in the non-hot flushes groups.Conclusion:The results suggest that the catabolic disorder of serotonin maybe involve in the underling mechanism of hot flushes in postmenopausal women.
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基本信息:
中图分类号:R711.75
引用信息:
[1]陈亚琼,吴维光.Changes of Plasma Concentration of 5-hydroxytryptamine and 5-hydroxyindoleacetic acid in climacteric women with hot flushes[J].生殖医学杂志,2007(S1):89-92.
2007-12-15
2007-12-15