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<正> Objective:To explore the characteristics of bone mineral density(BMD)and treatment inChinese patients with complete androgen insensitivity syndrome(CAIS).Methods:Fourteen cases of CAIS were studied retrospectively through analyzing and compa-ring BMD of pre-and post-gonadectomy with healthy Chinese men and women.BMD at the lum-bar spine and the femur were measured by dual energy X-ray absorptiometry(DXA).Results:There were 10 cases of CAIS having pre-gonadectomy DXA,in which 6 cases hadvery significantly reduced lumbar 2-4 BMD[(0.92±0.08)g/cm2]comparing with both healthymen and women(P<0.01),5 cases had significantly reduced femur neck BMD[(0.89±0.12)g/cm2]comparing with healthy men(P<0.05).There were 7 cases having 12 post-gonadectomyDXA,in which all lumbar 2-4 BMD[(0.954-0.06)g/cm2]were reduced very significantly com-paring with both healthy men and women(P<0.01),femur neck BMD[(0.91±0.08)g/cm2]were also reduced significantly comparing with healthy men(P<0.01)and women(P<0.05).Conclusion:There were different degrees of osteopenia in patients of CAIS,especially inlumbar vertebra.This suggests that both estrogen and androgen play important roles in the ac-quirement and maintenance of peak bone mass.
Abstract：Objective:To explore the characteristics of bone mineral density(BMD)and treatment in Chinese patients with complete androgen insensitivity syndrome(CAIS). Methods:Fourteen cases of CAIS were studied retrospectively through analyzing and compa- ring BMD of pre-and post-gonadectomy with healthy Chinese men and women.BMD at the lum- bar spine and the femur were measured by dual energy X-ray absorptiometry(DXA). Results:There were 10 cases of CAIS having pre-gonadectomy DXA,in which 6 cases had very significantly reduced lumbar 2-4 BMD[(0.92±0.08)g/cm2]comparing with both healthy men and women(P<0.01),5 cases had significantly reduced femur neck BMD[(0.89±0.12) g/cm2]comparing with healthy men(P<0.05).There were 7 cases having 12 post-gonadectomy DXA,in which all lumbar 2-4 BMD[(0.954-0.06)g/cm2]were reduced very significantly com- paring with both healthy men and women(P<0.01),femur neck BMD[(0.91±0.08)g/cm2] were also reduced significantly comparing with healthy men(P<0.01)and women(P<0.05). Conclusion:There were different degrees of osteopenia in patients of CAIS,especially in lumbar vertebra.This suggests that both estrogen and androgen play important roles in the ac- quirement and maintenance of peak bone mass.
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基本信息:
中图分类号:R711.6
引用信息:
[1]田秦杰,戴志琴,余卫,等.Study of bone mineral density in Chinese patients with complete androgen insensitivity syndrome[J].生殖医学杂志,2005(S1):33-37.
2005-10-28
2005-10-28