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近年来肿瘤患者年轻化趋势愈发明显,同时肿瘤患者生存率不断提高,因此年轻肿瘤患者生育力保存的问题备受关注。青春期后肿瘤患者保存生育能力的首选策略是卵母细胞或胚胎冷冻。卵母细胞或胚胎冷冻技术的实施均依赖于控制性促排卵(COH),卵巢过度刺激综合征(OHSS)是辅助生殖技术过程中与COH相关的严重并发症。本文报告了1例行卵母细胞冷冻方式保存生育功能的乳腺癌患者,采用高孕激素状态下促排卵方案(PPOS)促排卵,使用促性腺激素释放激素激动剂(GnRH-a)扳机,取卵后当天给予长效GnRH-a制剂行化疗前卵巢功能保护,取卵后第6天发生了重度OHSS。本文对该病例的诊疗经过进行分析,并对乳腺癌患者行生育力保存中预防OHSS的临床经验、教训进行总结,旨在为此类患者的临床诊治提供一定的警示。
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基本信息:
中图分类号:R711.75
引用信息:
[1]伍克佳,洪志丹,马玲.乳腺癌术后生育力保存发生重度卵巢过度刺激综合征1例并文献复习[J].生殖医学杂志,2024,33(11):1530-1534.
基金信息:
武汉大学中南医院学科建设项目(xkjs202001)
2024-11-15
2024-11-15