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不明原因反复胚胎种植失败(URIF)和不明原因反复流产(URSA)是临床上常见的两种既密切相关又有所区别的疾病，给患者带来了躯体及心理上的伤害，也增加了经济上的负担，如何明确其病因仍是个难题。近年来随着对疾病研究的深入，越来越多既往未明的致病因素得以发现和明确，URIF和URSA的比例在逐渐缩小。本文通过综合对比URIF和URSA两者的定义、可能的病因以及病因间存在的差异，为临床诊治和科研工作提供参考。
Abstract：Unexplained recurrent implantation failure(URIF) and unexplained recurrent spontaneous abortion(URSA) are two common clinical diseases that are closely related but different. They not only bring physical and psychological harm to patients, but also increase the economic burden. How to clarify their etiologies is still a difficult problem. In recent years, with the in-depth study on human diseases, more and more previously unknown pathogenic factors have been found and confirmed, and the proportion of URIF and URSA is gradually lessening. By comprehensively comparing definitions, possible etiologies and etiological differences between URIF and URSA,this review provides references for clinical diagnosis, therapy and scientific research.
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基本信息:
中图分类号:R714.21
引用信息:
[1]曾中虹,杨一华.不明原因反复胚胎种植失败和不明原因反复流产的病因学差异[J].生殖医学杂志,2022,31(07):998-1003.
基金信息:
国家自然科学基金面上项目(81871172); 广西自然科学基金杰出青年科学基金项目(2019GXNSFFA245013);广西自然科学基金重点项目(2018GXNSFDA050017); 2019年教指委研究课题(YX2019-03-03)
2021-11-11
2021
2021-12-18
2022-05-26
2022
1
2022-07-15
2022-07-15