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目的探讨体外受精-胚胎移植(IVF-ET)后单卵双胎妊娠与胚胎透明带显微操作的关系。方法回顾分析在我院行IVF-ET后获得临床妊娠的1,099个周期,比较行胚胎透明带显微操作(ZPM)和未经显微操作的两组患者单卵双胎(MZT)妊娠的发生率。结果IVF-ET后临床妊娠1,099周期中,MZT16周期,发生率为1.46%,占多胎的7.6%。显微操作组临床妊娠462周期,MZT6周期,发生率为1.30%;无显微操作组临床妊娠637周期,MZT10周期,发生率为1.60%,两组无显著差异(P>0.05)。结论单卵双胎妊娠与胚胎透明带显微操作之间无密切联系,积极控制IVF-ET的多胎妊娠可能是减少单卵双胎的有效途径。
Abstract：Objective: To assess the association of zona pellucida micromanipulation(ZPM)and monozygotic twinning(MZT) after in vitro fertilization and embryo transfer(IVF-ET).Methods: The pregnancies achieved by IVF-ET in our hospital during January 2000-December 2005 were retrospectively analyzed.The incidence of monozygotic twinning after ZPM was compared with that of zona intact subgroups.Results: A total of 2,859 cycles were performed,resulting in 1,099 clinical pregnancies,16 cases of monozygotic twins were identified,representing an overall frequency of 1.46%.Of the multiple pregnancies,7.6% contained MZT.There was no difference in the rate of pregnancies with MZT after zona pellucida micromanipulation procedures(1.3%) compared to zona intact subgroups(1.6%)(6/462 vs.10/637,P>0.05).Conclusion: Zona pellucida manipulation procedures are not associated with an increased incidence of monozygotic twinning in IVF-ET treatment cycles.
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基本信息:
中图分类号:R714.2
引用信息:
[1]张琪瑶,管群,菅福琴,等.胚胎透明带显微操作与单卵双胎妊娠[J].生殖医学杂志,2007(06):383-386.
2007-12-15
2007-12-15