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随着社会压力增大,青中年人群抑郁症患病率日益增高。《2022国民抑郁症蓝皮书》显示,19~40岁的抑郁症患者比例为65.14%,处于育龄期内的人群长期使用抗抑郁药物是否会对其生殖功能造成影响尚无明确结论。本文列举了目前临床常用的抗抑郁药物[包括三环/四环类抗抑郁药物、选择性五羟色胺(5-HT)再摄取抑制剂、5-HT与去甲肾上腺素(NE)再摄取抑制剂、褪黑素类及中药制剂等],系统总结了不同类型药物对生殖功能的影响,以期为育龄期抑郁症患者的用药选择提供一定参考。
Abstract:With the increase of social pressure, the prevalence of depression is increasing in young and middle-aged patients. 2022 National Depression Blue Book showed that the proportion of depressed patients aged 19 to 40 was 65.14%. It is worth pondering whether long-term use of antidepressants will affect the reproductive function of women in childbearing age. This paper lists the current commonly used antidepressants in clinical practice, including tricyclic/tetracyclic antidepressants, selective serotonin(5-HT) reuptake inhibitor, 5-HT and norepinephrine(NE) reuptake inhibitor, melatonin and traditional Chinese medicine preparations, and systematically summarizes the impact of different types of drugs on reproductive function, with a view to providing some reference for the choice of drugs for patients with depression at childbearing age.
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基本信息:
中图分类号:R971.43
引用信息:
[1]张安妮,刘阿慧,张学红.抗抑郁药物对生殖功能影响的研究进展[J].生殖医学杂志,2023,32(08):1286-1290.
基金信息:
兰州大学第一医院院内基金项目(ldyyyn-2021-65)
2022-11-27
2022
2023-01-09
2023-07-10
2023
1
2023-08-15
2023-08-15