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2025, 11, v.34 1569-1574
脂肪因子在子宫内膜容受性中的作用及机制进展
基金项目(Foundation): 江西省卫生健康委科技计划项目(202510070); 江西省自然科学基金(20242BAB25446); 国家自然科学基金(82260315)
邮箱(Email): huangjialv_medicine@foxmail.com;
DOI:
投稿时间: 2025-01-19
投稿日期(年): 2025
修回时间: 2025-04-04
终审时间: 2025-10-09
终审日期(年): 2025
审稿周期(年): 1
发布时间: 2025-11-15
出版时间: 2025-11-15
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摘要:

良好的子宫内膜容受性是胚胎成功着床与妊娠维持的关键因素,涉及复杂的分子间作用。近年来的研究表明脂肪因子在这一过程中扮演着重要角色。它们通过影响子宫内膜的炎症状态、代谢环境、激素反应和细胞功能等不同方面,参与胚胎与母体间的交互对话。这些发现不仅为理解胚胎植入失败的机制赋予了新的视角,也为治疗相关的生殖障碍提供潜在治疗靶点。本综述旨在总结多种脂肪因子对子宫内膜容受性的调控作用及相关机制,以期为未来的转化应用提供思路和方向。

Abstract:

Good endometrial receptivity is a crucial factor for successful embryo implantation and pregnancy maintenance, involving complex molecular interactions. In recent years, emerging studies have revealed that adipokines play an important role in this process. Their participation in the maternal-fetal crosstalk involves various aspects, such as the inflammatory state, metabolic environment, hormonal response, and cellular function of the endometrium. These findings not only provide new perspectives for understanding the mechanisms underlying embryo implantation failure, but also offer potential therapeutic targets for treating related reproductive disorders. This review aims to summarize the regulatory roles and mechanisms of adipokines in endometrial receptivity, thus providing insights and directions for future translational applications.

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基本信息:

中图分类号:R714.8

引用信息:

[1]谢琦琦,范露,万新霞,等.脂肪因子在子宫内膜容受性中的作用及机制进展[J].生殖医学杂志,2025,34(11):1569-1574.

基金信息:

江西省卫生健康委科技计划项目(202510070); 江西省自然科学基金(20242BAB25446); 国家自然科学基金(82260315)

投稿时间:

2025-01-19

投稿日期(年):

2025

修回时间:

2025-04-04

终审时间:

2025-10-09

终审日期(年):

2025

审稿周期(年):

1

发布时间:

2025-11-15

出版时间:

2025-11-15

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