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转化生长因子 -α( TGF-α)是人类发现的第一个多肽类的有丝分裂原——表皮生长因子 ( EGF)家族的重要成员。TGF-α是通过与 EGF-α是通过与 EGR受体结合 ,激活胞内信号转导通路 ,调节转录因子的活性和细胞增生等细胞行为 ,发挥其促进器官发生、创伤愈合、组织修复和肿瘤发生等生理、病理作用。胚胎发育和胚泡着床过程受到多种生长因子的调控。着床前胚泡的内细胞团和滋养外胚层细胞均表达 TGF-α及其受体 EGF受体 ,围植入期的输卵管和子宫也表达TGF-α。体内外的实验均证实 TGF-α能够促进胚胎的发育。 TGF-α尤其是其膜结合型的前体在子宫植入窗期的特异性表达提示其在胚胎植入过程中具有调控作用。但其具体作用机制尚不清楚 ,有待进一步研究
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基本信息:
中图分类号:R321
引用信息:
[1]陈舒怡,段恩奎.转化生长因子-α及其在胚胎发育和胚泡着床中的作用[J].生殖医学杂志,2002(01):51-54.
基金信息:
国家重点基础研究专项 (G19990 5 5 90 3);; 国家攀登计划 (970 2 110 193);; 中国科学院“百人计划”资助项目
2002-02-28
2002-02-28