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多囊卵巢综合征(PCOS)是一种表现为高雄激素、LH/FSH>2～3等激素水平紊乱、糖代谢异常为特征的异质性疾病,可致女性月经失调、肥胖、不孕等。外泌体(exosomes)是一种纳米级别的膜性微囊泡,其含有丰富的生物成分和影响多种器官系统的能力,因此可能成为具有诊断价值的标记物。本文就卵泡液来源的外泌体介导多囊卵巢综合征的发病研究进展做一综述,为外泌体协助疾病的诊断、治疗奠定基础。
Abstract：Polycystic Ovary Syndrome(PCOS)is one of endocrine and metabolic abnormalities of heterogeneous disorders,characterized by high androgen hormone level,LH/FSH >2-3 and abnormal glucose metabolism,which can lead to menstrual disorder,obesity and infertility,etc.Exosome is a kind of nanoscale membranous vesicles.At present,on account of its rich biological components and the ability to affect multiple organ systems,exosome may be the most potential diagnosis biomarker.This paper reviews the research progress in the pathogenesis of polycystic ovary mediated by exosome derived from follicular fluid to lay the foundation for diagnosis and treatment of the disease assisted by exosome.
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基本信息:
中图分类号:R711.75
引用信息:
[1]刘琳,彭小彧,张晓梅,等.外泌体在多囊卵巢综合征中的研究进展及其检测手段[J].生殖医学杂志,2019,28(08):976-979.
基金信息:
国家自然科学青年基金(81601343);; 中央级公益性科研院所基本科研业务项目(2017GJM01);; 扬州市自然基金(YZ2016110);; 国家科技基础性工作专项(2013FY110500);; 江苏省青年医学人才(QNRC2016345);; 江苏省六大人才高峰(WSW-197);; 国家人类遗传资源共享服务平台项目(2005DKA21300)
2019-08-14
2019-08-14