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目的 探讨精子DNA碎片率(DFI)与精液质量的关系以及对IVF周期胚胎质量的影响。方法 回顾性分析2021年6月至2023年4月于我院行IVF助孕的343对不孕不育夫妇的临床资料，按精子DFI分为A组(DFI<25%,n=294)和B组(DFI≥25%,n=49),分析精子DFI与精液常规参数的关系，以及不同精子DFI组胚胎质量的差异。结果 两组间男女方年龄、不孕年限、女方生殖激素水平、体质量指数(BMI)、获卵数比较均无统计学差异(P>0.05);A组优质囊胚形成率显著高于B组(P<0.05),而组间受精率、卵裂率、优质胚胎形成率、囊胚形成率比较均无统计学差异(P>0.05)。相关性分析显示，精子DFI与精子前向运动百分比(r=-0.239,P=0.000)、精子正常形态率(r=-0.254,P=0.000)呈负相关。结论 精子DFI与精液质量相关，并影响到IVF周期中优质囊胚的形成。
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基本信息:
中图分类号:R711.6
引用信息:
[1]成校,谢章平,何韶坚,等.精子DNA碎片率与精液质量、胚胎质量的相关性研究[J].生殖医学杂志,2024,33(06):809-812.
2024-06-15
2024-06-15