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目的 探讨慢性子宫内膜炎(CE)药物治疗后对体外受精-胚胎移植(IVF-ET)妊娠结局的影响。方法 回顾性分析于2015年1月至2020年12月在西北妇女儿童医院行因不孕症合并CE行IVF-ET治疗的243例患者(CE组)的临床资料。CE组患者IVF-ET前均药物治疗子宫内膜炎。基于倾向值1∶1匹配同期宫腔形态正常行IVF-ET治疗的243例非CE患者(对照组)。妊娠结局主要观察指标为临床妊娠率和活产率，次要观察指标为HCG阳性率、胚胎种植率、异位妊娠率、流产率和早产率。结果 CE组患者体质量指数(BMI)显著高于对照组[(21.59±3.33) kg/m2 vs.(20.94±2.89) kg/m2,P<0.05],原发性不孕占比显著高于对照组(67.49%vs. 57.20%,P<0.05)。与对照组比较，CE组新鲜周期移植临床妊娠率(57.61%vs. 60.08%)和活产率(49.38%vs. 50.21%)略低，但无统计学差异(P>0.05);两组患者间HCG阳性率、胚胎种植率、异位妊娠率、早产率和流产率均无统计学差异(P>0.05)。结论 慢性子宫内膜炎药物治疗后并不影响IVF-ET妊娠结局。
Abstract：Objective:To investigate the effects of drug therapy for chronic endometritis(CE) on pregnancy outcomes of IVF-ET.Methods:The clinical data of infertile 243 patients combined with CE(CE group) who underwent IVF-ET treatment in Northwest Women's and Children's Hospital from January 2015 to December 2020 were analyzed retrospectively. All CE patients received standardized drug therapy for CE before IVF-ET. Based on the propensity value of 1∶1,a total of 243 non-CE patients with normal uterine cavity morphology in the same period were treated with IVF-ET as the control group. Clinical pregnancy rate and live birth rate were the main pregnancy outcome. Meanwhile, chemical pregnancy rate, implantation rate, ectopic pregnancy rate, premature birth rate and miscarriage rate were taken as secondary end-points.Results:The body mass index(BMI)[(21.59±3.33) kg/m2 vs.(20.94±2.89) kg/m2,P<0.05] and primary infertility ratio(67.49% vs. 57.20%,P<0.05) of CE group were significantly higher than that of control group. The clinical pregnancy rate(57.61% vs. 60.08%) and live birth rate(49.38% vs. 50.21%) in CE group were slightly lower than those in control group, but there were no significant differences(P>0.05). There were no significant differences in HCG positive rate, implantation rate, ectopic pregnancy rate, premature birth rate and miscarriage rate between the two groups(P>0.05).Conclusions:After standardized treatment, chronic endometritis does not affect IVF-ET outcomes.
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基本信息:
中图分类号:R711.32
引用信息:
[1]段海霞,魏婷,李梦,等.慢性子宫内膜炎药物治疗后对体外受精-胚胎移植妊娠结局的影响[J].生殖医学杂志,2022,31(07):954-958.
基金信息:
西安市科技局项目[20YXYJ0005(9)]
2022-07-15
2022-07-15