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低促性腺激素性性腺功能减退症可导致有生育需求的女性患者出现原发性闭经而不孕。本文报道1例特发性低促性腺激素性性腺功能减退症合并卵巢储备功能减退的患者,外院行辅助生殖技术助孕3个周期未获得可利用胚胎,此次治疗给予生长激素长程预处理、改良促排卵方案促排卵后获得优质卵裂期胚胎,行鲜胚移植后临床妊娠并顺利单胎活产的诊疗经过;同时对相关文献进行复习,以期为该类患者的治疗决策提供一些资料积累和参考。
Abstract:[1] 王恺,卞陈晨,聂晓伟,等.一例SOX10基因突变所致的特发性低促性腺激素性性腺功能减退症的诊治分析[J].生殖医学杂志,2025,34:1108-1113.
[2] Zhang CM,Zhang H,Yang R,et al.The reproductive outcome of women with hypogonadotropic hypogonadism in IVF[J].Front Endocrinol (Lausanne),2022,13:850126.
[3] Xu W,Li R,Qiao J.ART outcomes of patients in women with Isolated Hypogonadotropic Hypogonadism:a retrospective study in China[J].BMC Pregnancy Childbirth,2023,23:255.
[4] Zacharin MR.Puberty,contraception,and hormonal management for young people with disabilities[J].Clin Pediatr (Phila),2009,48:149-155.
[5] 王含必,温晓晓,汤鲜,等.低促性腺激素性性功能不全妇女IVF-ET治疗中的方法及疗效分析[J].中国计划生育学杂志,2017,25:318-322.
[6] Jiao Z,Bukulmez O.Potential roles of experimental reproductive technologies in infertile women with diminished ovarian reserve[J].J Assist Reprod Genet,2021,38:2507-2517.
[7] Devesa J,Caicedo D.The role of growth hormone on ovarian functioning and ovarian angiogenesis[J].Front Endocrinol (Lausanne),2019,10:450.
[8] Yovich JL,Regan SLP,Zaidi S,et al.The concept of growth hormone deficiency affecting clinical prognosis in IVF[J].Front Endocrinol (Lausanne),2019,10:650.
[9] Homburg R,Eshel A,Abdalla HI,et al.Growth hormone facilitates ovulation induction by gonadotrophins[J].Clin Endocrinol (Oxf),1988,29:113-117.
[10] 蒙亚晴,周红,邓曦和,等.生长激素不同用药频次对高龄患者IVF/ICSI助孕临床结局的影响[J].中国计划生育和妇产科,2024,16:83-87.
[11] Ata B,Seyhan A,Seli E.Diminished ovarian reserve versus ovarian aging:overlaps and differences[J].Curr Opin Obstet Gynecol,2019,31:139-147.
[12] 王葳,汤美玲,周晓燕,等.生长激素在卵巢储备功能减退病人体外受精-胚胎移植拮抗剂方案中的临床应用[J].安徽医药,2023,27:1840-1844.
[13] 邬晓琳,黄玲玲,梁蕾,等.重组人生长激素在人类辅助生殖技术助孕中的应用进展[J].中华生殖与避孕杂志,2020,40:241-245.
[14] Li XL,Wang L,Lv F,et al.The influence of different growth hormone addition protocols to poor ovarian responders on clinical outcomes in controlled ovary stimulation cycles:A systematic review and meta-analysis[J].Medicine (Baltimore),2017,96:e6443.
[15] Gong Y,Zhang K,Xiong D,et al.Growth hormone alleviates oxidative stress and improves the IVF outcomes of poor ovarian responders:a randomized controlled trial[J].Reprod Biol Endocrinol,2020,18:91.
基本信息:
中图分类号:R714.8
引用信息:
[1]王艺璇,何红梅,曹国华,等.生长激素预处理低促性腺激素性性腺功能减退症反复助孕失败患者获得活产1例[J].生殖医学杂志,2026,35(05):676-679.
2026-05-15
2026-05-15