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卵泡液作为卵母细胞生长和分化的整体环境,直接或间接影响卵母细胞的生长和发育潜能,研究卵泡液中代谢物质的水平,可以间接反映卵细胞代谢水平。卵泡液代谢组学研究将可能成为临床上选择配子和胚胎的一项重要的非侵害性检测技术。本文从卵泡液代谢物组概况、卵泡液代谢物组与卵母细胞发育、早期卵裂和胚胎质量、妊娠结局几方面作简要综述。
Abstract：Follicular fluid as the whole environment of oocyte growth and differentiation directly or indirectly affects oocyte growth and development potential.Metabolites qualitative level in follicular fluid can indirectly reveal egg cell metabolism level.Follicular fluid metabolomics research could become an important noninvasive detection technology to choose gamete and embryo.This paper reviews the recent progress in follicular fluid metabolomics from follicular fluid metabolites composition and its relationship with oocyte quality,early cleavage,embryo quality,pregnancy outcome.
[1]Tweeddale H,Notley-McRobb L,Ferenci T.Effect of slow growth on metabolism of Escherichia coli,as revealed by global metabolite pool("metabolome")analysis[J].J Bacteriol.1998,180:5109-5116.
[2]Goodacre R,Vaidyanathan S,Dunn WB,et al.Metabolomics by numbers:acquiring and understanding global metabolite data[J].Trends Biotechnol,2004,22:245-252.
[3]Nicholson JK,Lindon JC,Holmes E.'Metabonomics':understanding the metabolic responses of living systems to pathophysiological stimuli via multivariate statistical analysis of biological NMR spectroscopic data[J].Xenobiotica,1999,29:1181-1189.
[4]Deepinder F,Chowdary HT.Agarwal A.Role of metabolomic analysis of biomarkers in the management of male infertility[J],Expert Rev Mol Diagn,2007,7:351-358.
[5]Revelli A,Delle Piane L,Casano S,et al.Follicular fluid content and oocyte quality:from single biochemical markers to metabolomics[J].Reprod Biol Endocrinol,2009,7:40.
[6]Pinero-Sagredo E,Nunes S,de Los Santos MJ.et al.NMR metabolic profile of human follicular fluid[J].NMR Biomed,2010,23:485-495.
[7]McRae CBaskind NE.Orsi NM.et al.Metabolic profiling of follicular fluid and plasma from natural cycle in vitro fertilization patients-a pilot study[J].Fertil Steril,2012,98:1449-1457.
[8]Arya BK.Haq AU.Chaudhury K.Oocyte quality reflected by follicular fluid analysis in poly cystic ovary syndrome(PCOS):a hypothesis based on intermediates of energy metabolism[J].Med Hypotheses,2012,78:475-478.
[9]Bender K,Walsh S,Evans AC,et al.Metabolite concentrations in follicular fluid may explain differences in fertility between heifers and lactating cows[J].Reproduction,2010,139,1047-1055.
[10]Valckx SD,De Pauw I,De Neubourg D,et al.BMI-related metabolic composition of the follicular fluid of women undergoing assisted reproductive treatment and the consequences for oocyte and embryo quality[J].Hum Reprod,2012,27,3531-3539.
[11]Jimena P,Castilla JA,Peran F,et al.Distribution of free amino acids in human preovulatory follicles[J].Horm Metab Res,1993,25:228-230.
[12]Sinclair KD,Lunn LA,Kwong WY,et al.Amino acid and fatty acid composition of follicular fluid as predictors of invitro embryo development[J/OL],Reprod Biomed online,2008,16:859-868.
[13]林楠,冯云,牛志宏,等.人卵泡液氨基酸谱影响卵母细胞发育潜能的初步研究[J].中国优生与遗传杂志,2012,20:100-102.
[14]Wallace M.Cottell E.Gibney MJ,et al.An investigation into the relationship between the metabolic profile of follicular fluid,oocyte developmental potential,and implantation outcome[J].Fertil Steril,2012,97,1078-1084.
[15]Lee TH,Lee MS,Liu CH,et al.The association between microenvironmental reactive oxygen species and embryo development in assisted reproduction technology cycles[J],Reprod Sci,2012,19:725-732.
[16]Pacella L,Zander-Fox DL,Armstrong DT.et al.Women with reduced ovarian reserve or advanced maternal age have an altered follicular environment[J].Fertil Steril,2012,98:986-994.
[17]夏兰,赵晓明,孙赞,等.反复IVF失败患者卵泡液代谢组学的检测分析[J].生殖与避孕,2012,32:248-253.
[18]Bedaiwy MA,Elnashar SA,Goldberg JM,et al.Effect of follicular fluid oxidative stress parameters on intracytoplasmic sperm injection outcome[J].Gynecol Endocrinol.2012,28:51-55.
基本信息:
中图分类号:R714.8
引用信息:
[1]姜晓媛,孙振高,连方,等.卵泡液代谢组学研究进展[J].生殖医学杂志,2013,22(11):888-891.
基金信息:
国家自然科学基金资助项目(30672706,81072836);; 山东省自然科学基金(专项)项目(2009ZRB14306);; 2009年度高校博士点专项科研基金联合资助项目(20093731110006)
2013-11-15
2013-11-15