生殖医学杂志

目的 探讨梅毒螺旋体抗体（TPPA）阳性患者行IVF-ET治疗的临床结局。方法 回顾性分析2015年1月1日至2020年12月31日于我院生殖医学中心行IVF-ET助孕治疗的479例不孕不育患者及其配偶的临床资料。根据TPPA检测结果分为3组：单独男方TPPA检测结果为阳性的为A组（n=59），单独女方TPPA检测结果为阳性的为B组（n=80），男女双方TPPA检测结果均阴性的为C组（n=340），比较各组患者的基本情况、助孕指标及妊娠结局。结果 各组间女性患者基本情况比较均无显著差异（P>0.05）;A组和B组的正常受精率、正常卵裂率、优质胚胎率、囊胚形成率均显著低于C组（P<0.05）;A组和B组的临床妊娠率、胚胎种植率均显著低于C组（P<0.05），而各组间异位妊娠率、多胎妊娠率、早产率比较均无显著差异（P>0.05）。结论 单独男方或者单独女方TPPA阳性均会影响胚胎继续发育潜能，并降低胚胎的种植率和临床妊娠率。

Objective:To investigate the effect of positive treponema pallidum antibody(TPPA)on the IVF-ET outcome.Methods:The clinical data of 479 infertile patients who received IVF-ET assisted pregnancy treatment in our reproductive medicine center from January 1,2015 to December 31,2020 were retrospectively analyzed.They were divided into three groups:only man with positive TPPA in group A(n=59),only woman with positive TPPA in group B(n=80),both spouses with negative TPPA test in group C(n=340).The basic conditions,pregnancy assistance indexes and pregnancy outcomes of patients in each group were compared.Results:There was no significant difference in the basic data of female patients among the groups(P>0.05).The normal fertilization rate,normal cleavage rate,high-quality embryo rate and blastocyst formation rate in group A and B were significantly lower than those in group C(P<0.05).The clinical pregnancy rate and implantation rate in group A and B were significantly lower than those in group C(P<0.05).There was no significant difference in ectopic pregnancy rate,multiple pregnancy rate and preterm birth rate among the groups(P>0.05).Conclusions:The positive TPPA in either male or female alone will affect the embryo's continued development potential and reduce the implantation rate and clinical pregnancy rate.