| 1,110 | 11 | 104 |
| 下载次数 | 被引频次 | 阅读次数 |
卵巢纤维化是多种妇科疾病的共同病理表现之一,卵巢早衰、子宫内膜异位囊肿、多囊卵巢综合征等均会造成卵巢纤维化;主要形成原因是卵巢组织细胞受损超过了周围实质细胞的修复能力,为了维持组织结构的完整性,细胞外基质大量产生并过度沉积,导致卵巢组织内结缔组织增多,实质细胞减少,最终造成卵巢不可逆修复而发生纤维化。卵巢纤维化的形成与许多细胞因子有关,本文将就卵巢纤维化相关疾病的影响因子、临床表现及其治疗方法的研究进展作简要介绍。
Abstract：Ovarian fibrosis is one of the common pathological manifestations of many gynecological diseases such as premature ovarian failure, endometriotic cysts, polycystic ovary syndrome, etc. The main cause of ovarian fibrosis is dysfunction of the surrounding parenchymal cells to repair the damaged ovarian tissue cells. Extracellular matrix is produced in large quantities and excessively deposited for maintaining the integrity of the organization. It causes the increase of connective tissue and the decrease of parenchymal cells in the ovary. Irreversible repair of the ovary leads to ovarian fibrosis in the end. Many cytokines are related to the process of ovarian fibrosis. This paper briefly introduces the progress of the influencing factors, clinical manifestations and treatment of ovarian fibrosis related diseases.
[1] Kinoshita T,Goto T.Molecular mechanisms of pulmonary fibrogenesis and its progression to lung cancer:a review[J].Int J Mol Sci,2019,20:1461.
[2] Ayd?n MM,Ak?al? KC.Liver fibrosis[J].Turk J Gastroenterol,2018,29:14-21.
[3] Harlow CR,Davidson L,Burns KH,et al.FSH and TGF-beta superfamily members regulate granulosa cell connective tissue growth factor gene expression in vitro and in vivo[J].Endocrinology,2002,143:3316-3325.
[4] Cheng JC,Chang HM,Fang L,et al.TGF-β1 up-regulates connective tissue growth factor expression in human granulosa cells through Smad and ERK1/2 signaling pathways[J/OL].PLoS One,2015,10:e0126532.
[5] Chang JZ,Yang WH,Deng YT,et al.EGCG blocks TGFβ1-induced CCN2 by suppressing JNK and p38 in buccal fibroblasts[J].Clin Oral Investig,2013,17:455-461.
[6] Chu YL,Xu YR,Yang WX,et al.The role of FSH and TGF-β superfamily in follicle atresia[J].Aging(Albany NY),2018,10:305-321.
[7] Wang L,Zhuang T,Li F,et al.Fluorene-9-bisphenol inhibits epithelial-mesenchymal transition of human endometrial cancer Ishikawa cells by repressing TGF-β signaling pathway[J].Environ Sci Pollut Res Int,2019,26:27407-27413.
[8] Lin S,Yu L,Ni Y,et al.Fibroblast growth factor 21 attenuates diabetes-induced renal fibrosis by negatively regulating TGF-β-p53-Smad2/3-Mediated epithelial-to-mesenchymal transition via activation of AKT[J].Diabetes Metab J,2020,44:158-172.
[9] Shim KY,Eom YW,Kim MY,et al.Role of the renin-angiotensin system in hepatic fibrosis and portal hypertension[J].Korean J Intern Med,2018,33:453-461.
[10] Viana GE,Pereira VM,Honorato-Sampaio K,et al.Angiotensin-(1-7) induces ovulation and steroidogenesis in perfused rabbit ovaries[J].Exp Physiol,2011,96:957-965.
[11] Zannad F,Rossignol P.Cardiorenal syndrome revisited[J].Circulation,2018,138:929-944.
[12] Wang C,Luo H,Xu Y,et al.Salvianolic acid B-alleviated angiotensin II induces cardiac fibrosis by suppressing NF-κB pathway in vitro[J].Med Sci Monit,2018,24:7654-7664.
[13] Su Q,Zhang Y.Glaucocalyxin A attenuates angiotensin II-induced cardiac fibrosis in cardiac fibroblasts[J].Biochem Biophys Res Commun,2018,503:1949-1954.
[14] Hrabia A,Wolak D,Kwa■.Expression of gelatinases(MMP-2 and MMP-9) and tissue inhibitors of metalloproteinases(TIMP-2 and TIMP-3) in the chicken ovary in relation to follicle development and atresia[J].Theriogenology,2019,125:268-276.
[15] Deady LD,Shen W,Mosure SA,et al.Matrix metalloproteinase 2 is required for ovulation and corpus luteum formation in Drosophila[J/OL].PLoS Genet,2015,11:e1004989.
[16] Chatterjee K,Jana S,DasMahapatra P,et al.EGFR-mediated matrix metalloproteinase-7 up-regulation promotes epithelial-mesenchymal transition via ERK1-AP1 axis during ovarian endometriosis progression[J].Faseb J,2018,32:4560-4572.
[17] Yao Y,Xu Y,Wang Y.Protective roles and mechanisms of rosmarinic acid in cyclophosphamide-induced premature ovarian failure[J].J Biochem Mol Toxicol,2020,34:e22591.
[18] Manshadi MD,Navid S,Hoshino Y,et al.The effects of human menstrual blood stem cells-derived granulosa cells on ovarian follicle formation in a rat model of premature ovarian failure[J].Microsc Res Tech,2019,82:635-642.
[19] 李婧.经阴道多普勒超声诊断卵巢早衰的应用价值评估与分析[J].中国医药指南，2017,15:153-154.
[20] Kawamura K,Kawamura N,Hsueh AJ.Activation of dormant follicles:a new treatment for premature ovarian failure?[J].Curr Opin Obstet Gynecol,2016,28:217-222.
[21] Zhang Q,Bu S,Sun J,et al.Paracrine effects of human amniotic epithelial cells protect against chemotherapy-induced ovarian damage[J].Stem Cell Res Ther,2017,8:270.
[22] Ganatra B,Gerdts C,Rossier C,et al.Global,regional,and subregional classification of abortions by safety,2010-14:estimates from a Bayesian hierarchical model[J].Lancet,2017,390:2372-2381.
[23] 崔晓平.用宫腔用交联透明质酸钠凝胶预防人工流产术后宫腔粘连的效果观察[J].当代医药论丛，2019,17:33-34.
[24] Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome(PCOS)[J].Hum Reprod,2004,19:41-47.
[25] Yang J,Zhong T,Xiao G,et al.Polymorphisms and haplotypes of the TGF-β1 gene are associated with risk of polycystic ovary syndrome in Chinese Han women[J].Eur J Obstet Gynecol Reprod Biol,2015,186:1-7.
[26] Wang D,Wang W,Liang Q,et al.DHEA-induced ovarian hyperfibrosis is mediated by TGF-β signaling pathway[J].J Ovarian Res,2018,11:6.
[27] Irani M,Seifer DB,Grazi RV,et al.Vitamin D supplementation decreases TGF-β1 bioavailability in PCOS:a randomized placebo-controlled trial[J].J Clin Endocrinol Metab,2015,100:4307-4314.
[28] Wallace WH,Thomson AB,Kelsey TW.The radiosensitivity of the human oocyte[J].Hum Reprod,2003,18:117-121.
[29] 徐安然，邓晓惠.放化疗致卵巢损害的机制及其组织学改变[J].国外医学(计划生育/生殖健康分册),2006,25:333-336.
[30] Mantawy EM,Said RS,Abdel-Aziz AK.Mechanistic approach of the inhibitory effect of chrysin on inflammatory and apoptotic events implicated in radiation-induced premature ovarian failure:Emphasis on TGF-β/MAPKs signaling pathway[J].Biomed Pharmacother,2019,109:293-303.
[31] Liu W,Wang HY.Differential studies of ovarian endometriosis cells from endometrium or oviduct[J].Eur Rev Med Pharmacol Sci,2016,20:2769-2772.
[32] Zondervan KT,Becker CM,Koga K,et al.Endometriosis[J].Nat Rev Dis Primers,2018,4:9.
[33] Viganò P,Ottolina J,Bartiromo L,et al.Cellular components contributing to fibrosis in endometriosis:A literature review[J].J Minim Invasive Gynecol,2020,27:287-295.
[34] Zeng X,Yue Z,Gao Y,et al.NR4A1 is involved in fibrogenesis in ovarian endometriosis[J].Cell Physiol Biochem,2018,46:1078-1090.
[35] Lee D,Kim SK,Lee JR,et al.Management of endometriosis-related infertility:Considerations and treatment options[J].Clin Exp Reprod Med,2020,47:1-11.
[36] Wu D,Lu P,Mi X,et al.Exosomal miR-214 from endometrial stromal cells inhibits endometriosis fibrosis[J].Mol Hum Reprod,2018,24:357-365.
基本信息:
中图分类号:R711.75
引用信息:
[1]胡周,南亚楠,刘佳,等.卵巢纤维化相关疾病与影响因子研究进展[J].生殖医学杂志,2021,30(04):554-559.
基金信息:
国家自然科学基金(81673764)
2020-09-09
2020
2020-10-19
2021-02-25
2021
1
2021-04-15
2021-04-15