生殖医学杂志

对辽宁省 １９９０～１９９２ 年 ３ 年中 ８ ５０８ 例病残儿童及其父母进行流行病学回顾、追踪性调查。结果：病残儿母 亲有异常分 娩 １５５９％ 、妊娠并 发症 ２９４７％ 、孕期 合并感染 ２４８９％ 、既 往不良妊 娠史７７３％ 、孕 期 接 触 理 化 环 境 １７８５％ 、孕 期 服 药 １２２４％ ； 病 残 儿 父 亲 接 触 理 化 环 境 ２１５９％ 、感 染５３０％ 、长期服药 １３５％ 。病残儿的父母近亲婚配率为 １３６％ ，有 ２２５ 人患有明显的先天性和遗传性疾病。经逐步回归分析，患先天性遗传性疾病、异常分娩、孕期用药、孕期感染、妊娠并发症是导致病残儿的主要危险因素。

Objectives: To study the risk factors in handicapped children. Subjects: 8 508 handicapped children in all regions of Liaoning province from 1990 to 1992 were investigated. Methods: A retrospective epidemiological investigation of the handicapped children by reviewing and trailing method. The risk factors of handicapped children were demonstrated by Logistic regression analysis. Results: There was 15 59% abnormal deliveries, 29.47% complicated pregnancies, 7.73% abnormal pregnant outcomes among the handicapped children's mothers; 17.85% contacted physical or chemical factors, 24.89% infectious factors, and 12.24% with history of drug intake during pregnancy. In their fathers, there was 21.59% contacting physical and chemical factors, 5 30% infectious factors, and 1 35% with history of long term drug intake. Consanguineous marriage rate of handicapped children's parents was 1 36%, among which 225 had congenital or hereditary diseases. Conclusion: The major risk factors for handicapped children were congenital inheritance disease, abnormal delivery, drug intake, infection, and complicated pregnancy of their mothers.