生殖医学杂志

目的 探索基于微信平台的干预对预防绝经后女性骨质疏松发生的效果，为未来骨质疏松的预防提供依据。方法 选取2021年1—12月在秦皇岛市第一医院骨科进行体检的50～60岁、骨量减少、愿意参加研究的绝经后女性240名，随机分为干预组和对照组，每组各120名。对照组接受常规的基本公共卫生服务，干预组在对照组基础上通过微信群对患者进行为期6个月的基于知信行理论设计的健康教育干预。比较两组干预前后的骨密度、骨质疏松相关知识知晓情况、自我效能和行为改变情况等。结果 经过为期6个月的干预，干预组的平均骨密度高于对照组[(106.8±22.1) mg/cm³ vs.(101.3±21.6) mg/cm³],但无显著差异(P=0.052),与干预前相比亦无显著差异(P=0.926)。双重差分模型分析结果显示，在考虑了基线的情况下，为期6个月的干预对于改善骨质疏松相关知识、运动效能、饮食行为以及运动行为有效(P<0.05)。结论 基于知信行理论设计的依托微信平台在绝经后女性人群中开展骨质疏松预防干预是可行的、有效的，未来需要针对目标人群开展相关的干预，进一步减少骨质疏松的发生。

Objective:To explore the effect of Wechat-based intervention on the prevention of osteoporosis in postmenopausal women, and to provide evidence for the prevention of osteoporosis in the future.Methods:A total of 240 postmenopausal women with bone loss aged 50-60 years and willing to participate in the study who underwent physical examination in the Orthopedics Department of the First Hospital of Qinhuangdao City from January 2021 to December 2021 were recruited and randomly divided into the intervention group and the control group, with 120 in each group. The control group received routine basic public health services, and the intervention group received a six-month health education intervention based on the theory of knowledge, attitude and practice through Wechat group. Bone mineral density, knowledge about osteoporosis, self-efficacy and behavior change were compared between the two groups before and after intervention.Results:After 6 months of intervention, the mean bone mineral density of the intervention group was higher than that of the control group [(106.8±22.1) mg/cm³ vs.(101.3±21.6) mg/cm³],but showing no significant difference(P=0.052),and there was no significant difference compared with before intervention(P=0.926). The results of difference-in-difference model analysis showed that the 6-month intervention was effective in improving osteoporosis-related knowledge, exercise self-efficacy, diet behavior and exercise behavior(P<0.05),when taking into account baseline.Conclusions:It is feasible and effective to carry out osteoporosis prevention intervention in postmenopausal women by relying on Wechat platform designed based on the theory of knowledge, attitude and practice. In the future, relevant intervention should be carried out for the target population to further reduce the occurrence of osteoporosis.