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卵巢癌是女性癌症相关死亡的第五大原因,也是40岁以上女性中第二大最常见的恶性肿瘤,仅次于乳腺癌。碳点(CDs)作为一种具有多种结构和特殊物理化学性质的新型纳米材料,在卵巢癌的靶向生物成像和治疗方面的潜在应用引起了人们的关注。CDs因其良好的生物相容性、合成材料稳定性简单、细胞毒性低等特点,在生物成像和生物医学等领域有着广泛的应用价值。本文综述了CDs结合糖类抗原125(CA125)、人附睾蛋白4(HE4)以及β-半乳糖苷酶(β-Gal)对卵巢癌的早期诊断和CDs对于卵巢癌治疗方面的研究进展。
Abstract:Ovarian cancer is the fifth leading cause of cancer-related deaths in women and the second most common malignant tumor in women over the age of 40,followed by breast cancer. Carbon dots(CDs),as a novel nanomaterial with multiple structures and unique physicochemical properties, have attracted attention for their potential applications in targeted biological imaging and the treatment of ovarian cancer. CDs have a wide range of applications in fields such as bioimaging and biomedicine due to their good biocompatibility, simple stability of synthetic materials, and low cytotoxicity. This paper reviews the research progress in the early diagnosis of ovarian cancer by CDs combined with carbohydrate antigen 125(CA125),human epididymis protein 4(HE4),and β-galactosidase(β-Gal) and CDs for the treatment of ovarian cancer.
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基本信息:
中图分类号:R737.31
引用信息:
[1]赵亮,李伟瑜,高嘉伟,等.碳点在卵巢癌诊断和治疗的研究进展[J].生殖医学杂志,2025,34(07):1010-1013.
基金信息:
兰州大学创新创业项目(20220060077,20250060164)
2025-07-15
2025-07-15