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目的探索低剂量人绒毛膜促性腺激素(HCG)既可以诱发卵母细胞成熟及排卵,又不影响体外受精-胚胎移植(IVF-ET)的临床结局。方法在IVF-ET长方案超促排卵方案中,具有卵巢过度刺激综合征(OHSS)高危因素的患者根据HCG日使用不同剂量的HCG分成2组:HCG 2 000U组(101人)和HCG 6 000U组(98人),分别比较两组的年龄、基础FSH水平、获卵率、受精率、优质胚胎率、临床妊娠率、OHSS发生率、流产率等。结果 HCG 6 000U组和2 000U组经比较,年龄、基础FSH值基本相同(P>0.05)。HCG 2 000U组中HCG日雌二醇(E2)水平及卵泡数均比HCG 6 000U组略高,但差异均无统计学意义(P>0.05)。HCG 2 000 U组获卵率比HCG 6 000 U组显著下降(71.4%vs.75.2%)(P<0.05);HCG 2 000U组和HCG 6 000U组的临床妊娠率分别为57.9%、57.1%,中度OHSS发生率分别为1.98%、8.2%,重度OHSS发生率分别是0和4.1%,HCG 2 000U组的中、重度OHSS发生率显著低于HCG 6 000U组(P<0.05)。结论低剂量HCG虽然影响获卵率、但是不影响临床妊娠率,且可以显著减少OHSS发生率。
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基本信息:
中图分类号:R714.8
引用信息:
[1]韦立红,黄品秀,韦继红.低剂量HCG诱发排卵在IVF卵巢过度刺激综合征高危人群中的应用研究[J].生殖医学杂志,2016,25(03):269-272.
2016-03-15
2016-03-15