| 162 | 4 | 101 |
| 下载次数 | 被引频次 | 阅读次数 |
<正>复发性流产(recurrent miscarriage,RM)病因复杂,其中约40%～60%原因不明。抗磷脂综合征(antiphospholipid syndrome,APS)是一种自身免疫性疾病,常伴持续性抗磷脂抗体(anti-phospholipidantibody,APA)阳性,是引起复发性流产的主要原因之一。APA在正常妇女中的阳性率为1%～5%,但在复发性流产妇女中可达到15%～50%。根据APA成分可将其分为两类,一类抗
Abstract：[1]Choudhury SR,KnappHuman LA.Reproductive failure I: Immunological factors[J].Hum Reprod Update.2001.7 (2):113-134.
[2]Vinatier D,Dufour P.Cosson M.et al.Antiphospholipid syndrome and recurrent miscarriage J].Eur J Obstet Gynecol,2001,96(1):37-50.
[3j Bao SH,Wang XP.Lin QD.et al.The Investigation on the Value of Repeat and Combination Test of ACA and Anti-β2 GPI Antibody in Women with Recurrent Spontaneous Abortion[J]. Am J Reprod Immunol.2008.60(4):372-378.
[4]Ruiz Irastorza G,Crowther M,Branch W.et al. Antiphospholipid syndrome[J].Lancel.2010,376(9751): 1498-1509.
[5]鲁爽,马旭.抗磷脂抗体与反复流产[J].中国计划生育学杂志,2006,1 27(5):31 7-318.
[6]余方流,刘辉.流产与血清抗心磷脂抗体相关性研究[J].皖南医学院学报,2002,21(2):97 98.
[7]李素萍,金玉霞,苗正友.不明原因反复自然流产患者的抗生殖免疫抗体分析[J].中国现代医生,2011,49(10): 134-135.
[8]Lockshin MD.Pregnancy loss and antiphospholipid antibodies[J].Lupus,1998.7(2 suppl):86 88.
[9]Stern C,Chamley LW.Hale L,et a..Antibodies to beta2 glycoprotein I are associated with in vitro fertilization implantation failure as well as recurrent miscarriage:results of a prevalence study[J].Fertil Steril,1998.70(5): 938-944.
[10]Forastiero RR,Martinuzzo ME,Cerrato GS.et al. Relationship of anti-beta2-glycoprotein I and antiprothrombin antibodies to thrombosis and pregnancy loss in patients with antiphospholipid antibodies[J].Thromb Haemost,1997,78(3):1008-1014.
[11]Falcon CR,Martinuzzo ME.Forastiero RR,et al.Pregnancy loss and autoantibodies against phospholipidbinding proteins[J],Obstet Gynecol,1997,89<6):975-980.
基本信息:
中图分类号:R714.21
引用信息:
[1]莫美兰,梁佩燕,蔡靖,等.复发性流产患者抗心磷脂抗体和抗β2-GPI抗体的检测与分析[J].生殖医学杂志,2012,21(05):486-488.
基金信息:
广东省医学科学技术研究基金(A2009626;B2010292);; 深港创新圈(ZYB200907090141A)资助
2012-10-15
2012-10-15