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2025, 09, v.34 1278-1283
多囊卵巢综合征患者子宫内膜容受性不良影响因素的研究进展
基金项目(Foundation): 中央引导地方科技发展资金项目(YDZJSX2022A069)
邮箱(Email): liujianrong3@sina.com;
DOI:
摘要:

排卵功能障碍是导致多囊卵巢综合征(PCOS)患者不孕的最主要原因,尽管无排卵及稀发排卵可以通过药物治疗得到一定的纠正,但PCOS患者的临床妊娠率仍然较低。即使通过辅助生殖技术体外受精筛选优质胚胎进行移植,也无法改变PCOS患者高着床失败及妊娠丢失率的现状,提示PCOS患者可能存在子宫内膜发育与分化障碍,包括接受胚胎能力下降、能量代谢异常、血液灌注差、子宫内膜慢性炎症等。本文针对PCOS患者子宫内膜容受性的变化及其受损的潜在机制进行综述,旨在为PCOS患者不孕症的治疗提供新的视角和可能的靶向干预策略。

Abstract:

Ovulatory dysfunction is the main cause of infertility in patients with polycystic ovary syndrome(PCOS).Although anovulation and oligoovulation can be treated to some extent through drug treatment,the clinical pregnancy rate of PCOS patients remains low.Even with the selection of highquality embryos through in vitro fertilization and subsequent transplantation,the high rate of implantation failure and pregnancy loss in PCOS patients cannot be changed,suggesting that there may be endometrial development and differentiation disorders in PCOS patients,including decreased receptivity,abnormal energy metabolism,poor blood perfusion,and chronic endometrial inflammation.This paper reviews some changes in endometrial receptivity in women with PCOS and discusses the potential mechanisms of its impairment,aiming to provide new perspectives and possible targeted intervention strategies for the treatment of infertility in PCOS patients.

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基本信息:

中图分类号:R711.75

引用信息:

[1]赵佳怡,康宜凡,刘建荣.多囊卵巢综合征患者子宫内膜容受性不良影响因素的研究进展[J].生殖医学杂志,2025,34(09):1278-1283.

基金信息:

中央引导地方科技发展资金项目(YDZJSX2022A069)

投稿时间:

2025-01-04

投稿日期(年):

2025

终审时间:

2025-08-06

终审日期(年):

2025

修回时间:

2025-03-22

审稿周期(年):

1

发布时间:

2025-09-15

出版时间:

2025-09-15

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