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目的 分析影响卵巢储备功能下降(DOR)患者宫腔内人工授精(IUI)助孕结局的因素。方法 回顾性分析2021年1月至2025年2月于吉林大学中日联谊医院和吉林省人民医院生殖医学中心接受宫腔内人工授精(IUI)治疗的DOR患者的资料，共纳入1 221例DOR患者的2 357个IUI周期。观察DOR患者IUI助孕结局，比较不同结局组临床资料，并通过多因素Logistic回归分析DOR患者IUI助孕结局的影响因素。结果 所纳入DOR患者IUI周期的临床妊娠率为11.96%(282/2 357)。临床妊娠组与未临床妊娠组患者间男女方年龄、文化程度、居住地比较均无统计学差异(P>0.05);相较于未临床妊娠组，临床妊娠组女方体质量指数(BMI)更低、不孕年限更短、抗苗勒管激素(AMH)水平更高、基础卵泡刺激素(FSH)水平更低、基础窦卵泡数(AFC)更多(P<0.001),临床妊娠组促排卵周期占比更高(P<0.05),优势卵泡数更多(P<0.001)。Logistic回归分析显示，不孕年限[OR=3.557,95%CI(1.464,8.645)]、AMH[OR=0.601,95%CI(0.247,1.461)]、AFC[OR=0.506,95%CI(0.208,1.229)]、优势卵泡数量[OR=0.443,95%CI(0.182,1.076)]是DOR患者IUI助孕结局的独立影响因素(P<0.05)。结论 不孕年限是IUI助孕结局的风险因素，不孕年限长者临床妊娠率低；AMH、AFC、优势卵泡数量则是IUI助孕结局的保护因素。
Abstract：Objectives:To analyze the factors influencing the outcomes of intrauterine insemination(IUI) assisted pregnancy in patients with diminished ovarian reserve(DOR).Methods:A retrospective analysis was conducted on the data of DOR patients who received IUI treatment at the Reproductive Medicine Center of China-Japan Union Hospital of Jilin University and the Reproductive Medicine Center of Jilin Provincial People's Hospital from January 2021 to February 2025. A total of 2 357 cycles of 1 221 DOR patients were included. The IUI-assisted pregnancy outcomes of DOR patients were observed. Clinical data from different outcome groups were compared. Multivariate logistic analysis was conducted to analyze the factors influencing the IUI-assisted pregnancy outcomes of patients with DOR.Results:The clinical pregnancy rate of patients with DOR was 11.96%(282/2 357). There were no statistically significant differences in male and female age, male and female educational levels and place of residence between the clinical pregnancy group and the non-clinical pregnancy group(P>0.05). Compared with the non-clinical pregnancy group, the female body mass index(BMI) in the clinical pregnancy group was lower, the duration of infertility was shorter, the anti-Müllerian hormone(AMH) level was higher, the basal follicle-stimulating hormone(FSH) level was lower, and the basal antral follicle count(AFC) was greater(P<0.001). There was a statistically significant difference in the cycle protocols between the two groups(P<0.05),and the number of dominant follicles in the clinical pregnancy group was significantly higher than that of the non-pregnancy group(P<0.001). Logistic regression analysis showed the infertility duration [OR=3.557,95%CI(1.464,8.645)],AMH level [OR=0.601,95%CI(0.247,1.461)],AFC [OR=0.506,95%CI(0.208,1.229)] and the number of dominant follicles [OR=0.443,95%CI(0.182,1.076)] were independent factors influencing the IUI-assisted pregnancy outcomes in DOR patients(P<0.05).Conclusions:The duration of infertility is a risk factor for the outcomes of IUI assisted pregnancy, and the clinical pregnancy rates are lower among those with longer infertility duration; AMH,AFC and the number of dominant follicles are protective factors for the outcomes of IUI assisted pregnancy.
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基本信息:
中图分类号:R714.8
引用信息:
[1]苗盛,王艳,袁柳,等.卵巢储备功能下降患者宫腔内人工授精助孕结局的影响因素分析[J].生殖医学杂志,2026,35(01):30-36.
2026-01-15
2026-01-15