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目的探讨地屈孕酮联合小剂量肠溶阿司匹林在治疗复发性流产中的作用。方法将90例有复发性流产史的妇女随机分为三组,每组30例。第1组月经周期第3~25天每天口服肠溶阿司匹林25mg bid,排卵后给予口服地屈孕酮片10mg bid至孕12周;第2组月经周期第3~25天每天口服肠溶阿司匹林25mg bid,排卵后给予安慰剂至孕12周;第3组在相同时间给予安慰剂。统计分析三组的血浆血栓素A2和前列环素I2比值(TXA2/PGI2)、子宫动脉阻力指数(resistance index,RI)和流产率。结果地屈孕酮+肠溶阿司匹林组较安慰剂组,TXA2/PGI2显著降低(0.62±0.27vs.1.13±0.21)、子宫动脉搏动指数显著增高(1.20±0.13vs.1.01±0.04)、足月分娩率显著增高(96.70%vs.83.33%)(P均<0.05),而单纯阿司匹林组与安慰剂组比较,各观察指标均无显著差异(P>0.05)。结论地屈孕酮联合小剂量肠溶阿司匹林能有效减少复发性流产的发生。
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基本信息:
中图分类号:R714.21
引用信息:
[1]马丽,赵桂凤,郭永,等.地屈孕酮联合小剂量肠溶阿司匹林在治疗复发性流产中的作用[J].生殖医学杂志,2014,23(02):146-148.
2014-02-15
2014-02-15