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在卵母细胞发育成熟过程中,各细胞器之间有效、稳定的交流是保证其功能与质量的基础。内质网作为细胞钙储池,通过耦联结构与线粒体外膜相连,传递Ca2+信号,我们称该结构为线粒体相关内质网膜(Mitochondria associated membrane, MAM)。MAM在调控内质网应激、线粒体功能、细胞凋亡等生理活动以及神经退行性病变、心肌衰老等病理变化中多见报道。近年来的研究发现MAM在卵母细胞质量下降机制中也扮演重要角色。本文综述MAM的组成及相关蛋白组分,重点阐述其在卵母细胞成熟与发育中扮演的角色以及相关的研究进展。
Abstract：In the process of oocyte development and maturation, effective and stable communication between various organelles is the basis for ensuring its quality. The endoplasmic reticulum acts as a cellular Ca2+ storage pool and is tightly connected to the outer mitochondrial membrane through coupling structure to transmit Ca2+ signals. We call this special structure as “mitochondria associated membrane”(MAM). MAM regulates physiological activities, such as endoplasmic reticulum stress, mitochondrial function and apoptosis, as well as pathological changes such as neurodegenerative diseases and myocardial aging. More and more evidences. Recent studies have found that MAM also plays a vital role in the mechanism of oocyte quality decline. This paper reviews the composition and related protein components of MAM,focusing on its research progress related to oocyte maturation and development.
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基本信息:
中图分类号:R339.22
引用信息:
[1]戴王娟,覃莲菊,崔毓桂,等.卵母细胞中线粒体相关内质网膜结构与功能的研究进展[J].生殖医学杂志,2022,31(01):135-139.
基金信息:
国家自然科学基金(81730041); 国家重点研发项目(2017YFC1001602,2016YFC1000603); 江苏省卫生厅项目(YXZXB2016001)
2022-01-15
2022-01-15