nav emailalert searchbtn searchbox tablepage yinyongbenwen piczone journalimg journalInfo journalinfonormal searchdiv searchzone qikanlogo popupnotification paper paperNew
摘要:

子宫内膜容受性是影响辅助生殖技术(ART)成功的主要因素之一。在ART中遇到的各种异常子宫内膜,将会对胚胎着床产生不利影响。目前国内外尚无统一的异常子宫内膜诊疗的专家共识和临床指南。为了让临床医师在实施ART过程中更好地诊治异常子宫内膜,国内相关领域专家参考国内外现有的医学研究结果,结合我国具体情况,编写了"辅助生殖技术中异常子宫内膜诊治的中国专家共识",以达到规范诊疗辅助生殖技术中异常子宫内膜患者的目的。

Abstract:

Endometrial receptivity is one of the most important factors affecting the success of assisted reproductive technology(ART).The various abnormal endometrium encountered in ART may have negative effect on embryo implantation.So far,there was no consensus and clinical guideline on diagnosis and management of abnormal endometrium.In order to better manage abnormal endometrium in ART,Chinese experts in this field formulated this consensus,based on the current available results obtained from national and international studies and combined with the specific circumstances of our country.

参考文献

[1]Heger A,Sator M,Pietrowski D.Endometrial receptivity and its predictive value for IVF/ICSI outcome[J].Geburtshilfe Frauenheilkd,2012,72:710-715.

[2]Traub M,Arsdale A,Pal L,et al.Endometrial thickness,Caucasian ethnicity,and age predict clinical pregnancy following fresh blastocyst embryo transfer:a retrospective cohort[J].Reprod Biol Endocrinol,2009,7:33.

[3]Kim MH,Park IH,Yoo YJ,et al.endometrial injury may promote implantation in patients with increased endometrial thickness on the day of hCG administration[J].Fertil Steril,2013,100:388-392.

[4]Barker MA,Boehnlein LM,Kovacs P,et al.Follicular and luteal phase endometrial thickness and echogenic pattern and pregnancy outcome in oocyte donation cycles[J].J Assist Reprod Genet,2009,5:243-249.

[5]Kasius A,Smit JG,Torrance HL,et al.Endometrial thickness and pregnancy rates after IVF:a systematic review and meta-analysis[J]. Hum Reprod Update,2014,20:530-541.

[6]Zackova T,Jarvela IY,Tapanainen JS,et al.Assessment of endometrialandovariancharacteristicsusingthree dimensional power Doppler ultrasound to predict response in frozen embryo transfer cycles[J].Reprod Biol Endocrinol,2009,7:151.

[7]Gingold JA,Lee JA,Rodriguez-Purata J,et al.Endometrial pattern,but not endometrial thickness,affects implantation rates in euploid embryo transfers[J].Fertil Steril,2015,104:620-628.e5.

[8]Chien LW,Au HK,Chen PL,et al.Assessment of uterine receptivity by the endometrial-subendometrial blood flow distribution pattern in women undergoing in vitro fertilizationembryo transfer[J].Fertil Steril,2002,78:245-251.

[9]Kim A,Young Lee J,Ji Y,et al.Do endometrial movements affect the achievement of pregnancy during intrauterine insemination?[J].Int J Fertil Steril,2015,8:399-408.

[10]Zhu L,Xiao L,Che HS,et al.Uterine peristalsis exerts control over fluid migration after mock embryo transfer[J].Hum Reprod,2014,29:279-285.

[11]Zhu L,Che HS,Xiao L,et al.Uterine peristalsis before embryo transfer affects the chance of clinical pregnancy in fresh and frozen-thawed embryo transfer cycles[J].Hum Reprod,2014,29:1238-1243.

[12]Mahajan N,Sharma S.The endometrium in assisted reproductive technology:How thin is thin?[J].J Hum Reprod Sci,2016,9:3-8.

[13]Kupesic S,Bekavac I,Bjelos D,et al.Assessment of endometrial receptivity by transvaginal color Doppler and three-dimensional power Doppler ultrasonography in patients undergoing in vitro fertilization procedures[J].J Ultrasound Med,2001,20:125-134.

[14]Chen MJ,Yang JH,Peng FH,et al.Extended estrogen administration for women with thin endometrium in frozenthawed in-vitro fertilization programs[J].J Assist Reprod Genet,2006,23:337-342.

[15]Sher G,Fisch JD.Vaginal sildenafil(Viagra):apreliminary report of a novelmethod to improve uterine artery blood flow and endometrial development inpatients undergoing IVF[J].Hum Reprod,2000,15:806-809.

[16]Zinger M,Liu JH,Thomas MA.Successful use of vaginal sildenafil citrate intwo infertility patients with Asherman’s syndrome[J].J Womens Health(Larchmt),2006,15:442-444.

[17]Ledee-Bataille N,Olivennes F,Lefaix JL,et al.Combined treatment by pentoxifylline and tocopherol for recipient women with a thin endometrium enrolled in an oocyte donation programme[J].Hum Reprod,2002,17:1249-1253.

[18]Zhao J,Xu B,Xie S,et al.Whether G-CSF administration has beneficial effect on the outcome after assisted reproductive technology?A systematic review and meta-analysis[J].Reprod Biol Endocrinol,2016,14:62.

[19]Madafeiton MA,Bodombossou D,Zheng C,et al.Neuromuscular electrical stimulation and biofeedback therapy may improveendometrialgrowthforpatientswiththin endometrium during frozen-thrawed embryo transfer:a preliminary report[J].Reprod Biol Endocrinol,2011,9:122.

[20]Tan JC,Li P,Wang Q,et al.Autologous menstrual bloodderived stromal cells transplantation for severe Asherman’s syndrome[J].Hum Reprod,2016,31:2723-2729.

[21]Santamaria X,Cabanillas S,Cervello I,et al.Autologous cell therapy with CD133+bone marrow-derived stem cells for refractory Asherman’s syndrome and endometrial atrophy:a pilot cohort study[J].Hum Reprod,2016,31:1087-1096.

[22]AAGLAdvancingMinimallyInvasiveGynecology Worldwide.AAGL practice report:practice guidelines for management of intrauterine synechiae[J].J Minim Invasive Gynecol,2010,17:1-7.

[23]中华医学会妇产科学分会.宫腔粘连临床诊疗中国专家共识[J].中华妇产科杂志,2015,50:881-887.

[24]He RH,Gao HJ,Li YQ,et al.The associated factors to endometrial cavity fluid and the relevant impact on the IVFET outcome[J].Reprod Biol Endocrinol,2010,8:46.

[25]He Q,Tsang LL,Ajonuma LC,et al.Abnormally upregulated cystic fibrosis transmembrane conductance regulator expression and uterine fluid accumulation contribute to Chlamydia trachomatis-induced female infertility[J].Fertil Steril,2010,93:2608-2614.

[26]庄芳,赵美芳.经阴道超声诊断宫腔粘连的临床分析[J].实用妇科内分泌杂志(电子版),2016,3:56-59.

[27]Tower AM,Frishman GN.Cesarean scar defects:an underrecognized cause of abnormal uterine bleeding and other gynecologic complications[J].J Minim Invasive Gynecol,2013,20:562-572.

[28]Barbieri RL.Stenosis of the external cervical os:an association with endometriosis in women with chronic pelvic pain[J].Fertil Steril,1998,70:571-573.

[29]Griffiths AN,Watermeyer SR,Klentzeris LD.Fluid within the endometrial cavity in an IVF cycles-a novel approach to its management[J].J Assist Reprod Genet,2002,19:298-301.

[30]Liu S,Shi L,Shi J.Impact of endometrial cavity fluid on assisted reproductive technology outcomes[J]. Int J Gynaecol Obstet,2016,132:278-283.

[31]Akman MA,Erden HF,Bahceici M,et al.Endometrial fluid visualized through ultrasonography during ovarian stimulation in IVF cycles impairs the outcome in tubal factor,but not PCOS,patients[J].Hum Reprod,2005,20:906-909.

[32]He RH,Zhu XM.How to deal with fluid in the endometrial cavity during assisted reproductive techniques[J].Curr Opin Obstet Gynecol,2011,23:190-194.

[33]Kotaro K,Hidehiko M,Kehei Y,et al.Chronic endometritis:potential cause of infertility and obstetric and neonatal complications[J].Am J Reprod Immunol,2016,75:13-22.

[34]McQueen DB,Bernardi LA,Stephenson MD.Chronic endometritis in women with recurrent early pregnancy loss and/or fetal demise[J].Fertil Steril,2014,101:1026-1030.

[35]Hyun JP,You SK,Tae KY,et al.Chronic endometritis and infertility[J].Clin Exp Reprod Med,2016,43:185-192.

[36]Wu D,Kimura F,Zheng L,et al.Chronic endometritis modifies decidualization in human endometrial stromal cells[J].Reprod Biol Endocrinol,2017,15:16.

[37]Yuqing C,Ruili F,Yuanna L,et al.Analysis of the diagnostic value of CD138for chronic endometritis,the risk factor for the pathogenesis of chronic endometritis and the effect of chronic endometritis on pregnancy:a cohort study[J].BMC Womens Health,2016,16:60-66.

[38]Kurman R,Carcangiu M,Herrington C,et al.World Health Organisation classification of tumors of female reproductive organs[M].4th ed.Lyon,France:International Agency for Research on Cancer(IARC)Press,2014.

[39]全国卫生产业企业管理协会妇幼健康产业分会生殖内分泌学组.中国子宫内膜增生诊疗共识[J].生殖医学杂志,2017,26:957-960.

[40]Lowe MP,Cooper BC,Sood AK,et al.Implementation of assisted reproductive technologies following conservative management of FIGO grade I endometrial adenocarcinoma and/or complex hyperplasia with atypia[J].Gynecol Oncol,2003,91:569-572.

[41]Taieb S,Ceugnart L,Leblanc E,et al.MR imaging of endometrial carcinoma:role and limits[J].Bull Cancer,2002,89:963-968.

[42]Jadoul P,Donnez J.Conservative treatment may be beneficial for young women with atypical endometrial hyperplasia or endometrial adenocarcinoma[J].Fertil Steril,2003,80:1315-1324.

[43]Eleftheria K,Sean CD,Bakkum-Gamez JN.Preserving fertility in young patients with endometrial cancer:current perspectives[J].Int J Womens Health,2014,6:691-701.

[44]Baker J,Obermair A,Gebski V,et al.Efficacy of oral or intrauterine device-delivered progestin in patients with complex endometrial hyperplasia with atypia or early endometrial adenocarcinoma:a meta-analysis and systematic review of the literature[J].Gynecol Oncol,2012,125:263-270.

[45]Zapardiel I,Cruz M,Diestro MD,et al.Assisted reproductive techniques after fertility-sparing treatments in gynaecological cancers[J].Hum Reprod Update,2016,22:281-305.

[46]Gurgan T,Bozdag G,Demirol A,et al.Preserving fertility before assisted reproduction in women with endometrial carcinoma:case report and literature review[J/OL].Reprod Biomed Online,2007,15:561-565.

[47]Elizur SE,Beiner ME,Korach J,et al.Outcome of in vitro fertilization treatment in infertile women conservatively treated for endometrial adenocarcinoma[J].Fertil Steril,2007,88:1562-1567.

[48]Colombo N,Creutzberg C,Amant F,et al.ESMO-ESGOESTRO consensus conference on endometrial cancer:diagnosis,treatment and follow-up[J].Radiother Oncol,2015,117:559-581.

[49]Ichinose M,Fujimoto A,Osuga Y,et al.The influence of infertility treatment on the prognosis of endometrial cancer and atypical complex endometrial hyperplasia[J].Int J Gynecol Cancer,2013,23:288-293.

[50]Niwa K,Tagami K,Lian Z,et al.Outcome of fertilitypreserving treatment in young women with endometrial carcinoma[J].BOJG,2005,112:317-320.

[51]夏恩兰.妇科内镜学[M].北京:人民卫生出版社,2001:558-560.

[52]Fernandez-Parra J,Rodriguez Oliver A,Lopez Criado S,et al.Hysteroscopic evaluation of endometrial polyps[J].Int J Gynaecol Obstet,2006,95:144-148.

[53]Bosteels J,Kasius J,Weyers S,et al.Hysteroscopy for treating subfertility associated with suspected major uterine cavity abnormalities[DB/OL].Cochrane Database Syst Rev,2015,(2):CD009461.

[54]Tiras B,Korucuoglu U,Polat M,et al.Management of endometrial polyps diagnosed before or during ICSI cycles[J/OL].Reprod Biomed Online,2012,24:123-128.

[55]Lass A,Williams G,Abusheikha N,et al.The effect of endometrial polyps on outcomes of in vitro fertilization(IVF)cycles[J].J Assist Reprod Genet,1999,16;410-415.

[56]Yanaihara A,Yorimitsu T,Motoyama H,et al.Location of endometrial polyp and pregnancy rate in infertility patients[J].Fertil Steril,2008,90:180-182.

[57]Varasteh NN,Neuwirth RS,Levin B,et al.Pregnancy rates after hysteroscopic polypectomy and myomectomy in fertile women[J].Obstet Gynecol,1999,94:168-171.

[58]Zheng QM,Mao HI,Zhao YJ,et al.Risk of endometrial polyps in women with endometriosis:a meta-analysis[J].Reprod Biol Endocrinol,2015,13:103.

[59]Gu F,Zhang H,Ruan S,et al.High number of endometrial polyps is a strong predictor of recurrence:findings of a prospective cohort study in reproductive-age women[J].Fertil Steril,2018,109:493-500.

基本信息:

中图分类号:R714.8

引用信息:

[1]赵静,黄国宁,孙海翔,等.辅助生殖技术中异常子宫内膜诊疗的中国专家共识[J].生殖医学杂志,2018,27(11):1057-1064.

检 索 高级检索

引用

GB/T 7714-2015 格式引文
MLA格式引文
APA格式引文