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目的比较评估卵巢储备功能的常用指标在各年龄段对预测卵巢反应性的价值。方法回顾性分析1 478例行IVF/ICSI-ET助孕、符合入选标准的不孕女性的临床资料。根据年龄分为A组(≤30岁)、B组(30～38岁)、C组(>38岁);组内根据获卵数分为卵巢低反应组(<6个)、卵巢正常反应组(6～18个)及卵巢高反应组(>18个)。比较基础FSH(bFSH)、抗苗勒管激素(AMH)、基础雌二醇水平(bE2)及窦卵泡数(AFC)单独及联合应用在各年龄段对卵巢反应性的预测价值。结果 bFSH、AMH、AFC在各年龄组间及卵巢反应亚组间均有显著差异(P<0.01);bE2在各年龄组间及卵巢反应亚组间均无显著差异(P>0.05)。ROC曲线分析显示,单一指标预测卵巢反应性时,AMH的曲线下面积最大;联合指标对于预测30～38岁组卵巢低反应(联合bFSH、AMH、AFC)、>38岁组卵巢低反应(联合bFSH、AMH及年龄)和卵巢高反应(联合bFSH、AMH),可提高其ROC曲线下面积、预测敏感度和特异度。结论血清AMH作为单一指标预测卵巢反应性时,其预测价值最大;对于30～38岁女性,多项指标相联合可明显提高预测卵巢低反应的价值;对于>38岁的女性,多项指标相联合对卵巢低反应和高反应均可提高预测价值。
Abstract：Objective:To compare the value of common indicators used to assess ovarian reserve for predicting ovarian response in the patients of different ages.Methods:The data of 1 478 infertile women who underwent IVF/ICSI-ET and eligible for the inclusion criteria were retrospectively analyzed. They were divided into three groups according to the age:group A(age ≤30 years),group B(30
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基本信息:
中图分类号:R714.8
引用信息:
[1]魏景蕊,袁巾惠,白晶莹,等.评估卵巢储备功能的常用指标对预测卵巢反应性的价值比较[J].生殖医学杂志,2020,29(01):27-32.
基金信息:
河南省教育厅科技攻关项目(142300410240;162102310207)
2020-01-15
2020-01-15